结外口腔非霍奇金淋巴瘤。阿根廷40例病例的回顾性研究。

Extranodal oral non-Hodgkin's lymphomas. A retrospective study of 40 cases in Argentina.

作者信息

Keszler Alicia, Piloni María J, Paparella María L, Soler Marcela de Dios, Ron Patricia Cabrera, Narbaitz Marina

机构信息

Cátedra de Anatomía Patológica, Facultad de Odontología, Universidad de Buenos Aires, Argentina.

出版信息

Acta Odontol Latinoam. 2008;21(1):43-8.

PMID:18841745

Abstract

A retrospective study was conducted of extranodal oral Non-Hodgkin's Lymphomas diagnosed at the Surgical Pathology Laboratory of the School of Dentistry at Buenos Aires University, Argentina, between 1985 and 2004. The 40 cases found represent 0.2% of the oral biopsies diagnosed during that time and 4.6% of malignant neoplasias. Overall mean age of patients was 49.4 years, and frequency was greater in males. 80% affected soft tissues. Prevalent location was gingival, followed by palate. Intraosseous cases were more frequent in mandible (75%) than in upper maxilla. 100% of the cases were phenotype B, with a higher frequency of high-grade aggressiveness. The most common histological type was Diffuse Large Cell Lymphoma. 60% of the Plasmablastic Lymphomas in the series came from HIV+ patients. Evolution time prior to consultation was 1 to 3 months in 57.7% of the cases.

摘要

对1985年至2004年间在阿根廷布宜诺斯艾利斯大学牙科学院外科病理实验室诊断的结外口腔非霍奇金淋巴瘤进行了一项回顾性研究。发现的40例病例占该时间段内口腔活检诊断病例的0.2%，占恶性肿瘤的4.6%。患者的总体平均年龄为49.4岁，男性发病率更高。80%累及软组织。常见部位为牙龈，其次是腭部。骨内病例在下颌骨（75%）比在上颌骨更常见。100%的病例为B表型，高级别侵袭性频率更高。最常见的组织学类型是弥漫性大细胞淋巴瘤。该系列中60%的浆母细胞淋巴瘤来自HIV阳性患者。57.7%的病例在就诊前的病程为1至3个月。