Isikdogan Abdurrahman, Ayyildiz Orhan, Buyukcelik Abdullah, Arslan Adem, Tiftik Naci, Buyukbayram Huseyin, Muftuoglu Ekrem
Department of Hematology-Oncology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey.
Ann Hematol. 2004 May;83(5):265-9. doi: 10.1007/s00277-003-0812-0. Epub 2003 Nov 26.
We have carried out a retrospective analysis of 490 non-Hodgkin's lymphomas (NHLs), followed at our clinic, with the purpose of evaluating the clinicopathologic features of these patients. The patients were assessed with regard to their characteristics including age, gender, histologic distribution, stage, extranodal involvement, presenting symptoms, and biopsied site. Of the patients 314 (64%) were male and 176 (36%) were female. The overall median age was 43 years (range: 14-90). The patients were classified according to the Working Formulation (WF) system: 71 (14.4%) were low grade, 342 (69.8%) were intermediate grade, 43 (8.7%) were high grade, and 34 (6.7%) had other lymphomas. Intermediate-grade non-Hodgkin's lymphomas formed the largest group, of whom 320 patients' paraffin blocks were available for Revised European and American lymphoma (REAL) classification: 78% were B-cell lymphomas, whereas 16% were T/NK lymphomas. Six percent of cases were unclassified lymphomas. Diffuse large B-cell lymphoma (DLBCL) was the most commonly observed histopathologic type in 132 (41%) patients. Extranodal involvement was found in 218 (44.5%) patients. The most commonly affected extranodal sites were small bowel, stomach, and tonsil in 72 (33%), 63 (29%), and 19 (8.7%) patients, respectively. According to the Ann Arbor staging system, the vast majority of patients (89.4%) were advanced stage. In conclusion,The characteristics of NHLs in our region show some differences from the other sites of Turkey and the world.
我们对在我们诊所随访的490例非霍奇金淋巴瘤（NHL）进行了回顾性分析，目的是评估这些患者的临床病理特征。对患者的特征进行了评估，包括年龄、性别、组织学分布、分期、结外受累情况、首发症状和活检部位。患者中314例（64%）为男性，176例（36%）为女性。总体中位年龄为43岁（范围：14 - 90岁）。患者根据工作分类法（WF）系统进行分类：71例（14.4%）为低级别，342例（69.8%）为中级别，43例（8.7%）为高级别，34例（6.7%）为其他淋巴瘤。中级别的非霍奇金淋巴瘤构成最大组，其中320例患者的石蜡块可用于修订的欧美淋巴瘤（REAL）分类：78%为B细胞淋巴瘤，而16%为T/NK淋巴瘤。6%的病例为未分类淋巴瘤。弥漫性大B细胞淋巴瘤（DLBCL）是132例（41%）患者中最常见的组织病理学类型。218例（44.5%）患者存在结外受累。最常受累的结外部位分别是小肠、胃和扁桃体，各有72例（33%）、63例（29%）和19例（8.7%）患者。根据Ann Arbor分期系统，绝大多数患者（89.4%）为晚期。总之，我们地区NHL的特征与土耳其其他地区及世界其他地区存在一些差异。
