Plante E
Child Language Laboratory, University of Arizona, Tucson 85721.
Brain Lang. 1991 Jul;41(1):67-80. doi: 10.1016/0093-934x(91)90111-d.
Four families that include a specifically language-impaired (SLI) boy were studied to test the hypothesis that developmental language disorders are biologically transmittable. A majority of the parents of the SLI boys had experienced communication difficulty (i.e., difficulty with speech, language, or academic skills) as children. Evidence of communication difficulty was paired on an individual basis with neuroanatomical data obtained through quantitative analysis of magnetic resonance imaging scans. Atypical perisylvian asymmetries were documented in a majority of the parents and were frequently associated with a history of communication difficulty. Atypical perisylvian asymmetries and disordered language skills were also documented for siblings of SLI boys. These findings suggest that atypical perisylvian asymmetries reflect a transmittable, biological factor that places some families at risk for language impairment.
对四个包含特定语言障碍（SLI）男孩的家庭进行了研究，以检验发育性语言障碍具有生物遗传性这一假设。大多数患有SLI的男孩的父母在儿童时期都经历过沟通困难（即言语、语言或学术技能方面的困难）。沟通困难的证据与通过磁共振成像扫描定量分析获得的神经解剖学数据进行了个体配对。大多数父母都记录有非典型的颞周不对称，且常与沟通困难史相关。SLI男孩的兄弟姐妹也记录有非典型的颞周不对称和语言技能障碍。这些发现表明，非典型的颞周不对称反映了一种可遗传的生物因素，使一些家庭面临语言障碍的风险。
