Plante E, Swisher L, Vance R, Rapcsak S
Child Language Laboratory, University of Arizona, Tucson 85702.
Brain Lang. 1991 Jul;41(1):52-66. doi: 10.1016/0093-934x(91)90110-m.
Magnetic resonance imaging scans of specifically language-impaired (SLI) boys were examined to determine whether atypical cerebral findings could be documented in children whose primary deficits were in language skills. Clinical examination of the scans failed to reveal any visually obvious lesions or abnormalities. In contrast, measurement of the scans revealed atypical perisylvian asymmetries in most of these subjects. The distribution of perisylvian asymmetries in SLI subjects was significantly different from the distribution in controls (p less than .01). Measurement of other brain regions revealed that extraperisylvian areas were occasionally deviant in individual SLI subjects; but no one region was consistently deviant across the SLI group. Thus, only atypical perisylvian asymmetries were linked to the language disorder. These neuroanatomical findings suggest that a prenatal alteration of brain development underlies specific language impairment.
对特定语言障碍（SLI）男孩的磁共振成像扫描进行了检查，以确定在主要缺陷在于语言技能的儿童中是否能记录到非典型的脑部表现。对扫描结果的临床检查未发现任何明显的视觉病变或异常。相比之下，对扫描结果的测量显示，这些受试者中的大多数存在非典型的颞周不对称。SLI受试者中颞周不对称的分布与对照组的分布显著不同（p小于0.01）。对其他脑区的测量显示，在个别SLI受试者中，颞周外区域偶尔会出现异常；但在SLI组中没有一个区域始终存在异常。因此，只有非典型的颞周不对称与语言障碍有关。这些神经解剖学发现表明，大脑发育的产前改变是特定语言障碍的基础。
