Schramm F, Moenne-Loccoz R, Fafi-Kremer S, Soulier E, Royer C, Weitten T, Brignon N, Ellero B, Woehl-Jaegle M-L, Meyer C, Wolf P, Doffoel M, Baumert T-F, Gut J-P, Stoll-Keller F, Schvoerer E
Unité Inserm 748, 3, rue Koeberlé, 67000 Strasbourg, France.
Pathol Biol (Paris). 2008 Nov-Dec;56(7-8):487-91. doi: 10.1016/j.patbio.2008.07.007. Epub 2008 Oct 7.
Besides hepatocytes, representing the main replication site of hepatitis C virus, peripheral blood mononuclear cells also represent a crucial target for viral infection. Hepatitis C virus compartmentalization (i.e., non-random distribution) of viral variants between plasma and peripheral blood mononuclear cells, more frequently observed in liver transplant patients compared to non-transplanted patients, makes liver transplantation an interesting model for the analysis of hepatitis C leukotropism. This article aims to present, firstly, in clinical and biological features arguing favour of hepatitis C virus infection leukotropism and, secondly, to review current knowledge about compartmentalization between plasma and peripheral blood mononuclear cells, especially in the liver transplantation setting.
除了作为丙型肝炎病毒主要复制场所的肝细胞外，外周血单核细胞也是病毒感染的关键靶点。与未接受移植的患者相比，肝移植患者血浆与外周血单核细胞之间病毒变异体的丙型肝炎病毒分隔化（即非随机分布）更为常见，这使得肝移植成为分析丙型肝炎病毒嗜白细胞性的一个有趣模型。本文旨在首先阐述支持丙型肝炎病毒感染嗜白细胞性的临床和生物学特征，其次综述目前关于血浆与外周血单核细胞之间分隔化的知识，尤其是在肝移植背景下的知识。
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