Krel' P E, Tsinzerling O D
Ter Arkh. 2009;81(11):63-8.
The high incidence of recurrent chronic hepatitis C after a course of antiviral therapy determines the urgency of determining the extrahepatic reservoirs of hepatitis C virus (HCV). The most extrahepatic site for the virus is peripheral mononuclear cells (PMC). Assuming that there may be HCV replication in the PMC), these cells can be considered as a potential reservoir of HCV infection. The most common extrahepatic manifestation of HCV is cryoglobulinemia, the genesis of which may be active viral replication in the cells of the immune system. There is evidence that HCV is detectable just in the tissues of the involved organs. Thus, most systemic manifestations may be directly associated with extrahepatic HCV replication.
在接受一个疗程的抗病毒治疗后，复发性慢性丙型肝炎的高发病率决定了确定丙型肝炎病毒（HCV）肝外储存库的紧迫性。病毒最主要的肝外部位是外周单核细胞（PMC）。假设PMC中可能存在HCV复制，那么这些细胞可被视为HCV感染的潜在储存库。HCV最常见的肝外表现是冷球蛋白血症，其发生可能是免疫系统细胞中活跃的病毒复制所致。有证据表明，仅在受累器官的组织中可检测到HCV。因此，大多数全身表现可能与肝外HCV复制直接相关。
