等臂双着丝粒染色体18q作为弥漫性大细胞非霍奇金淋巴瘤患者组织学正常骨髓中的唯一异常。

Isodicentric chromosome 18q as sole abnormality in a histologically normal bone marrow from a patient with diffuse large-cell non-Hodgkin's lymphoma.

作者信息

Wurster-Hill D H, Vredenburgh J J, Davis B H, Mills L E, Ball E D

机构信息

Dartmouth-Hitchcock Medical Center, Durham, North Carolina.

出版信息

Cancer Genet Cytogenet. 1991 Jul 15;54(2):233-7. doi: 10.1016/0165-4608(91)90212-d.

DOI:10.1016/0165-4608(91)90212-d

PMID:1884356

Abstract

Cytogenetic analysis was performed on the histologically and immunophenotypically normal bone marrow (BM) of a 33-year-old woman with non-Hodgkin's lymphoma (NHL) before BM harvest. Unstimulated 24- and 48-hour cultures produced only normal metaphases. A pokeweed mitogen (PWM)-stimulated 48-hour culture, however, showed a clonal isodicentric chromosome 18q as the sole abnormality, suggesting a role for this approach in detection of submicroscopic BM involvement by B-cell NHL.

摘要

对一名33岁非霍奇金淋巴瘤（NHL）女性患者在采集骨髓前进行组织学和免疫表型均正常的骨髓细胞遗传学分析。未经刺激的24小时和48小时培养仅产生正常中期分裂相。然而，经美洲商陆有丝分裂原（PWM）刺激的48小时培养显示，唯一的异常是一条克隆性等臂双着丝粒18号染色体，提示该方法在检测B细胞NHL亚微观骨髓受累方面具有作用。