弥漫性非霍奇金淋巴瘤中11号染色体异常与t(14;18)的关联

Association of abnormalities of chromosome 11 with t(14;18) in diffuse non-Hodgkin's lymphoma.

作者信息

Lukeis R, Juneja S, Tan L, Matthews J, Cooper I, Ironside P, Garson O M

机构信息

Department of Cytogenetics, Peter MacCallum Cancer Institute, Melbourne, Australia.

出版信息

Cancer Genet Cytogenet. 1994 Nov;78(1):36-9. doi: 10.1016/0165-4608(94)90043-4.

DOI:10.1016/0165-4608(94)90043-4

PMID:7987803

Abstract

Cytogenetic studies of non-Hodgkin's lymphomas (NHL) have revealed a nonrandom translocation, t(14;18)(q32;q21), to be strongly correlated with follicular histology. In our recent study of 149 cases of NHL, 68 cases had a t(14;18). Forty-four of these were follicular and 24 diffuse. In the majority of cases (90%) there were additional chromosome abnormalities, which were analyzed to determine whether any were specifically associated with diffuse histology. Chromosome 11 abnormalities occurring together with the t(14;18) were found to be present in 17/68 cases; 14/17 (82%) were diffuse and 3/17 (18%) were follicular NHL. Thus, 14/24 (58%) of all diffuse lymphomas with t(14;18) had an abnormality of chromosome 11 compared to only 3/44 (7%) of follicular lymphomas, suggesting that the addition of an abnormality of chromosome 11 to a t(14;18) karyotype is associated with diffuse histology.

摘要

非霍奇金淋巴瘤（NHL）的细胞遗传学研究显示，一种非随机易位t(14;18)(q32;q21)与滤泡性组织学密切相关。在我们最近对149例NHL的研究中，68例存在t(14;18)。其中44例为滤泡性，24例为弥漫性。在大多数病例（90%）中还存在其他染色体异常，对这些异常进行分析以确定是否有任何异常与弥漫性组织学有特定关联。发现与t(14;18)同时出现的11号染色体异常存在于17/68例中；14/17（82%）为弥漫性，3/17（18%）为滤泡性NHL。因此，所有伴有t(14;18)的弥漫性淋巴瘤中有14/24（58%）存在11号染色体异常，而滤泡性淋巴瘤中只有3/44（7%）存在该异常，这表明在t(14;18)核型中添加11号染色体异常与弥漫性组织学相关。