Panani A D, Ferti-Passantonopoulou A, Raptis S
Second Department of Internal Medicine, Propaedeutic of Athens University, Evangelismos Hospital, Greece.
Cancer Genet Cytogenet. 1991 Jul 15;54(2):259-61. doi: 10.1016/0165-4608(91)90217-i.
We present here 3 of 30 cases of large bowel cancer cytogenetically studied, with deletion of chromosome 5. One of them presented a terminal deletion and the other two an interstitial deletion of chromosome 5q. In all three cases the segment 5q12-22 was deleted. Our findings may show that the segment 5q12-22 is important for a subgroup of colorectal cancers.
我们在此展示了30例经细胞遗传学研究的大肠癌病例中的3例，这些病例存在5号染色体缺失。其中1例呈现5号染色体末端缺失，另外2例为5号染色体长臂间质性缺失。在所有3例病例中，5q12 - 22区段均缺失。我们的研究结果可能表明，5q12 - 22区段对一部分结直肠癌具有重要意义。
