Delattre O, Olschwang S, Law D J, Melot T, Remvikos Y, Salmon R J, Sastre X, Validire P, Feinberg A P, Thomas G
Curie Institute, Paris, France.
Lancet. 1989 Aug 12;2(8659):353-6. doi: 10.1016/s0140-6736(89)90537-0.
Multiple genetic alterations were investigated in colorectal cancer, including changes in DNA content, mutations in ras oncogenes, and deletions involving chromosomes 5, 17, and 18. A non-random association of deletions and mitotic abnormalities by site was seen, with both types of alterations occurring significantly more frequently in distal tumours. In contrast, the frequency of c-Ki-ras mutations did not differ between proximal and distal cancers. In addition, deletions were significantly associated with each other and with change in DNA content. The data provide strong support for the hypothesis that proximal and distal colon carcinoma might differ in the genetic mechanisms in their initiation and/or progression.
在结直肠癌中研究了多种基因改变，包括DNA含量变化、ras癌基因突变以及涉及5号、17号和18号染色体的缺失。观察到按部位出现的缺失与有丝分裂异常存在非随机关联，两种改变类型在远端肿瘤中显著更频繁地发生。相比之下，近端和远端癌症中c-Ki-ras突变的频率没有差异。此外，缺失彼此之间以及与DNA含量变化显著相关。这些数据为近端和远端结肠癌在起始和/或进展的遗传机制上可能存在差异这一假说提供了有力支持。
