Zinkewich-Péotti K, Parent M, Morais R
Department of Biochemistry, Faculty of Medicine, University of Montreal, Quebec, Canada.
Cancer Lett. 1991 Aug;59(2):119-24. doi: 10.1016/0304-3835(91)90175-h.
We have examined the tumorigenic potential of mitochondrial DNA-depleted (mtDNA-) cells derived from the tumorigenic chicken cell line DU24. The mtDNA- cells were unable to proliferate in the wing web of day-old chicks. Cytoplasmic hybrids resulting from crosses between the mtDNA- whole cells and cytoplasts from enucleated parental cells (mtDNA+) recover both mtDNA and tumorigenicity. These results are in accordance with those obtained in prior experiments where mtDNA was shown to modulate the anchorage-independent phenotype of transformed avian cells.
我们检测了源自致瘤性鸡细胞系DU24的线粒体DNA缺失（mtDNA-）细胞的致瘤潜力。mtDNA-细胞无法在一日龄雏鸡的翼蹼中增殖。由mtDNA-全细胞与去核亲代细胞（mtDNA+）的细胞质体杂交产生的细胞质杂种恢复了mtDNA和致瘤性。这些结果与先前实验中所获得的结果一致，在先前实验中，mtDNA被证明可调节转化禽类细胞的非贴壁依赖性表型。
