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Tumorigenicity of simian virus 40-transformed human cells and mouse--human hybrids in nude mice.

作者信息

Koprowski H, Croce C M

出版信息

Proc Natl Acad Sci U S A. 1977 Mar;74(3):1142-6. doi: 10.1073/pnas.74.3.1142.

DOI:10.1073/pnas.74.3.1142
PMID:191830
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC430625/
Abstract

Four different human cell lines transformed by simian virus 40 (SV40) were tested for their tumorigenicity in athymic nude mice. Two of these lines, W18Va2 and GM52VA, were found to be tumorigenic when inoculated at a concentration of 1 x 10(7) cells per mouse. The other two cell lines, LN-SV and GM54VA, were found to induce very small tumors only after the injection of approximately 1 x 10(8) cells per mouse. Somatic cell hybrids between either LN-SV or GM54VA SV40-transformed human cells and normal mouse peritoneal macrophages, which have retained the human chromosomes carrying the SV40 genome, were found to be much more tumorigenic than the SV40-transformed human cell parents. These experiments suggest that the genetic background in which the human chromosomes carrying the SV40 genome are present plays a role in the modulation of the expiration of malignancy.

摘要

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Tumorigenicity of simian virus 40-transformed human cells and mouse--human hybrids in nude mice.
Proc Natl Acad Sci U S A. 1977 Mar;74(3):1142-6. doi: 10.1073/pnas.74.3.1142.
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Assignment of the integration site for simian virus 40 to chromosome 17 in GM54VA, a human cell line transformed by simian virus 40.在经猿猴病毒40转化的人类细胞系GM54VA中，将猿猴病毒40的整合位点定位到17号染色体上。
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Proc Natl Acad Sci U S A. 1973 Dec;70(12):3617-20. doi: 10.1073/pnas.70.12.3617.

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本文引用的文献

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DETECTION OF SPECIFIC ANTIGEN IN SV40-TRANSFORMED CELLS BY IMMUNOFLUORESCENCE.免疫荧光法检测SV40转化细胞中的特异性抗原
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Suppression of malignancy by cell fusion.通过细胞融合抑制恶性肿瘤
人类转化支气管上皮细胞系中与肿瘤发生性的自发获得和丧失相关的核型变化：转化克隆体内选择的证据
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Genetics of B-cell neoplasia.B细胞肿瘤的遗传学
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9
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10
Fibronectin expression is determined by the genotype of the transformed parental cells in heterokaryons between normal and transformed fibroblasts.在正常成纤维细胞与转化成纤维细胞之间的异核体中，纤连蛋白的表达由转化亲代细胞的基因型决定。
J Cell Biol. 1979 Jan;80(1):118-27. doi: 10.1083/jcb.80.1.118.
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4
Identification of the mouse karyotype by quinacrine fluorescence, and tentative assignment of seven linkage groups.通过喹吖因荧光鉴定小鼠核型，并初步确定七个连锁群。
Proc Natl Acad Sci U S A. 1971 Jul;68(7):1530-3. doi: 10.1073/pnas.68.7.1530.
5
The analysis of malignancy by cell fusion. I. Hybrids between tumour cells and L cell derivatives.通过细胞融合分析恶性肿瘤。I. 肿瘤细胞与L细胞衍生物之间的杂种细胞
J Cell Sci. 1971 May;8(3):659-72. doi: 10.1242/jcs.8.3.659.
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Assignment of nucleoside phosphorylase to D-14 and localization of X-linked loci in man by somatic cell genetics.通过体细胞遗传学将核苷磷酸化酶定位到D-14以及人类X连锁基因座的定位。
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Somatic cell hybrids between mouse peritoneal macrophages and SV40-transformed human cells. I. Positive control of the transformed phenotype by the human chromosome 7 carrying the SV40 genome.小鼠腹腔巨噬细胞与SV40转化的人细胞之间的体细胞杂种。I. 携带SV40基因组的人7号染色体对转化表型的阳性控制。
J Exp Med. 1974 Nov 1;140(5):1221-9. doi: 10.1084/jem.140.5.1221.
8
A nonselective analysis of SV40 transformation of mouse 3T3 cells.对小鼠3T3细胞的SV40转化进行的非选择性分析。
Virology. 1974 Jun;59(2):477-89. doi: 10.1016/0042-6822(74)90457-7.
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Assignment of the T-antigen gene of simian virus 40 to human chromosome C-7.将猴病毒40的T抗原基因定位于人类C-7染色体。
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3617-20. doi: 10.1073/pnas.70.12.3617.
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Effect of environmental pH on the efficiency of cellular hybridization.环境pH对细胞杂交效率的影响。
Proc Natl Acad Sci U S A. 1972 Jul;69(7):1953-6. doi: 10.1073/pnas.69.7.1953.