Uhr J W, Tucker T, May R D, Siu H, Vitetta E S
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235.
Cancer Res. 1991 Sep 15;51(18 Suppl):5045s-5053s.
Dormancy in the murine BCL1 lymphoma can be induced by several strategies including cytoreductive therapy of mice with large tumor burdens and challenge of allogeneic chimeric mice or idiotype-immunized mice with BCL1 tumor. Dormant tumor cells were isolated from the spleens of the chimeric mice and the majority were shown to be noncycling. In idiotype-immunized mice that had lost dormancy, tumor growth occurred at a relatively rapid rate. A proportion of idiotype-immunized mice that had lost dormancy spontaneously regressed and then again relapsed; in these mice, the serum antiidiotypic levels were inversely related to the tumor burden.
小鼠BCL1淋巴瘤的休眠可通过多种策略诱导，包括对肿瘤负荷大的小鼠进行细胞减灭疗法，以及用BCL1肿瘤对同种异体嵌合小鼠或独特型免疫小鼠进行攻击。从嵌合小鼠的脾脏中分离出休眠肿瘤细胞，大多数显示为非循环状态。在失去休眠的独特型免疫小鼠中，肿瘤生长速度相对较快。一部分失去休眠的独特型免疫小鼠肿瘤自发消退，然后再次复发；在这些小鼠中，血清抗独特型水平与肿瘤负荷呈负相关。
