Scuderi Caterina, Filippis Daniele De, Iuvone Teresa, Blasio Angelo, Steardo Antonio, Esposito Giuseppe
Department of Physiology and Pharmacology V Erspamer, Sapienza University of Rome, Rome, Italy.
Phytother Res. 2009 May;23(5):597-602. doi: 10.1002/ptr.2625.
Cannabidiol (CBD) is the main non-psychotropic component of the glandular hairs of Cannabis sativa. It displays a plethora of actions including anticonvulsive, sedative, hypnotic, antipsychotic, antiinflammatory and neuroprotective properties. However, it is well established that CBD produces its biological effects without exerting significant intrinsic activity upon cannabinoid receptors. For this reason, CBD lacks the unwanted psychotropic effects characteristic of marijuana derivatives, so representing one of the bioactive constituents of Cannabis sativa with the highest potential for therapeutic use.The present review reports the pharmacological profile of CBD and summarizes results from preclinical and clinical studies utilizing CBD, alone or in combination with other phytocannabinoids, for the treatment of a number of CNS disorders.
大麻二酚（CBD）是大麻腺毛的主要非精神活性成分。它具有多种作用，包括抗惊厥、镇静、催眠、抗精神病、抗炎和神经保护特性。然而，众所周知，CBD在不对大麻素受体产生显著内在活性的情况下产生其生物学效应。因此，CBD缺乏大麻衍生物特有的不良精神活性作用，是大麻中具有最高治疗应用潜力的生物活性成分之一。本综述报告了CBD的药理学概况，并总结了单独使用或与其他植物大麻素联合使用CBD治疗多种中枢神经系统疾病的临床前和临床研究结果。
