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Expert Rev Vaccines. 2008 Oct;7(8):1239-55. doi: 10.1586/14760584.7.8.1239.
2
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Gold nanoparticle-adjuvanted S protein induces a strong antigen-specific IgG response against severe acute respiratory syndrome-related coronavirus infection, but fails to induce protective antibodies and limit eosinophilic infiltration in lungs.金纳米颗粒佐剂 S 蛋白诱导针对严重急性呼吸综合征相关冠状病毒感染的强烈抗原特异性 IgG 反应，但不能诱导保护性抗体并限制肺部嗜酸性粒细胞浸润。
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本文引用的文献

1
CXCL10/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy.CXCL10/CXCR3介导的反应通过增强树突状细胞和CD8(+) T细胞的效能来促进对呼吸道合胞病毒感染的免疫力。
Eur J Immunol. 2008 Aug;38(8):2168-79. doi: 10.1002/eji.200838155.
2
Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein.在用呼吸道合胞病毒G糖蛋白免疫的小鼠中，肺部嗜酸性粒细胞增多需要白细胞介素-5、嗜酸性粒细胞趋化因子-1和CD4 + T细胞。
J Leukoc Biol. 2008 Sep;84(3):748-59. doi: 10.1189/jlb.0907621. Epub 2008 Jun 2.
3
Structure and ion channel activity of the human respiratory syncytial virus (hRSV) small hydrophobic protein transmembrane domain.人呼吸道合胞病毒（hRSV）小疏水蛋白跨膜结构域的结构与离子通道活性
Protein Sci. 2008 May;17(5):813-20. doi: 10.1110/ps.073366208. Epub 2008 Mar 27.
4
Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus.T细胞库多样性随年龄增长而下降，导致库中出现漏洞，并削弱对流感病毒的免疫力。
J Exp Med. 2008 Mar 17;205(3):711-23. doi: 10.1084/jem.20071140. Epub 2008 Mar 10.
5
Alveolar macrophages are a major determinant of early responses to viral lung infection but do not influence subsequent disease development.肺泡巨噬细胞是对病毒性肺部感染早期反应的主要决定因素，但不影响随后的疾病发展。
J Virol. 2008 May;82(9):4441-8. doi: 10.1128/JVI.02541-07. Epub 2008 Feb 20.
6
IL-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced disease.在呼吸道合胞病毒疫苗增强型疾病期间，嗜酸性粒细胞进入肺部需要白细胞介素-13。
J Immunol. 2008 Feb 15;180(4):2376-84. doi: 10.4049/jimmunol.180.4.2376.
7
Newcastle disease virus as a vaccine vector for humans.新城疫病毒作为人类疫苗载体。
Curr Opin Mol Ther. 2008 Feb;10(1):46-55.
8
Differential role of gamma interferon in inhibiting pulmonary eosinophilia and exacerbating systemic disease in fusion protein-immunized mice undergoing challenge infection with respiratory syncytial virus.γ干扰素在抑制呼吸道合胞病毒激发感染的融合蛋白免疫小鼠肺部嗜酸性粒细胞增多及加重全身疾病中的差异作用
J Virol. 2008 Mar;82(5):2196-207. doi: 10.1128/JVI.01949-07. Epub 2007 Dec 19.
9
Single intranasal immunization with recombinant adenovirus-based vaccine induces protective immunity against respiratory syncytial virus infection.用基于重组腺病毒的疫苗进行单次鼻内免疫可诱导针对呼吸道合胞病毒感染的保护性免疫。
J Virol. 2008 Mar;82(5):2350-7. doi: 10.1128/JVI.02372-07. Epub 2007 Dec 19.
10
CD8+ T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections.重度原发性呼吸道合胞病毒感染婴儿支气管肺泡灌洗液和外周血单核细胞中的CD8 + T细胞反应
J Immunol. 2007 Dec 15;179(12):8410-7. doi: 10.4049/jimmunol.179.12.8410.

肺部免疫与免疫病理学：来自呼吸道合胞病毒的经验教训。

Pulmonary immunity and immunopathology: lessons from respiratory syncytial virus.

作者信息

Olson Matthew R, Varga Steven M

机构信息

Department of Microbiology, Interdisciplinary Graduate Program in Immunology, 51 Newton Road, 3-532 Bowen Science Building, University of Iowa, Iowa City, IA 52242, USA.

出版信息

Expert Rev Vaccines. 2008 Oct;7(8):1239-55. doi: 10.1586/14760584.7.8.1239.

DOI:10.1586/14760584.7.8.1239
PMID:18844597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2630464/
Abstract

Respiratory syncytial virus (RSV) is the leading cause of severe respiratory disease in infants and is an important source of morbidity and mortality in the elderly and immunocompromised. This review will discuss the humoral and cellular adaptive immune responses to RSV infection and how these responses are shaped in the immature immune system of the infant and the aged environment of the elderly. Furthermore, we will provide an overview of our current understanding of the role the various arms of the adaptive immune response play in mediating the delicate balance between the successful elimination of the virus from the host and the induction of immunopathology. Efficacious immunization against RSV remains a high priority within the field and we will highlight recent advances made in vaccine design.

摘要

呼吸道合胞病毒（RSV）是婴儿严重呼吸道疾病的主要病因，也是老年人和免疫功能低下者发病和死亡的重要原因。本综述将讨论针对RSV感染的体液和细胞适应性免疫反应，以及这些反应在婴儿未成熟免疫系统和老年人衰老环境中的形成方式。此外，我们将概述目前对适应性免疫反应各分支在介导从宿主体内成功清除病毒与诱导免疫病理之间微妙平衡中所起作用的理解。针对RSV的有效免疫接种仍是该领域的高度优先事项，我们将重点介绍疫苗设计方面的最新进展。