Besson Hervé, Ekelund Ulf, Brage Søren, Luben Robert, Bingham Sheila, Khaw Kay-Tee, Wareham Nicholas J
Epidemiology Unit, Medical Research Council, Cambridge, United Kingdom.
Med Sci Sports Exerc. 2008 Nov;40(11):1909-15. doi: 10.1249/MSS.0b013e318180bcad.
The purpose of this study was to describe the association of the overall and domain-specific physical activity on all-cause and cardiovascular mortality. A large body of epidemiological evidence suggests a strong and consistent inverse association between physical activity and mortality risk. However, it is unclear how this association varies according to the domain of life in which the activity takes place.
In an English population-based cohort of 14,903 participants (mean age = 63 yr), total and domain-specific physical activity was assessed using a validated questionnaire (EPAQ2). After a median follow-up of 7 yr, there were 1128 deaths, with 370 from cardiovascular disease.
The relative risks (95% confidence interval) for all-cause mortality due to physical activity undertaken at home, during exercise, at work, for transport, and in total were 0.81 (0.66-0.99), 0.66 (0.54-0.80), 0.84 (0.55-1.30), 0.82 (0.67-1.00), and 0.77 (0.61-0.98), respectively, after adjustment for baseline age, sex, social class, alcohol consumption, smoking status, history of diabetes, history of cancer, and history of cardiovascular disease and stroke. Cardiovascular mortality was inversely associated with physical activity undertaken at home (P for trend = 0.03), during exercise (P for trend = 0.001), and in total (P for trend = 0.007). The results were unchanged after excluding individuals with a history of heart disease, stroke, and cancer at baseline and those who died within the first 2 yr of follow-up.
In this study, physical activities at home and during exercise are associated with lower risk of mortality, whereas occupational and transportation-related activities are not. Promoting the potential benefits of physical activity undertaken at home and during exercise may be an important public health message for aging populations.
本研究旨在描述总体身体活动及特定领域身体活动与全因死亡率和心血管疾病死亡率之间的关联。大量流行病学证据表明，身体活动与死亡风险之间存在强烈且一致的负相关。然而，尚不清楚这种关联如何因活动发生的生活领域而异。
在一个基于英国人群的队列中，有14903名参与者（平均年龄 = 63岁），使用经过验证的问卷（EPAQ2）评估总体及特定领域的身体活动。在中位随访7年后，有1128人死亡，其中370人死于心血管疾病。
在对基线年龄、性别、社会阶层、饮酒量、吸烟状况、糖尿病史、癌症史以及心血管疾病和中风史进行调整后，在家中、运动时、工作时、交通出行时以及总体身体活动导致的全因死亡率的相对风险（95%置信区间）分别为0.81（0.66 - 在0.99）、0.66（0.54 - 0.80）、0.84（0.55 - 1.30）、0.82（0.67 - 1.00）和0.77（0.61 - 0.98）。心血管疾病死亡率与在家中进行的身体活动（趋势P值 = 0.03）、运动时进行的身体活动（趋势P值 = 0.001）以及总体身体活动（趋势P值 = 0.007）呈负相关。在排除基线时有心脏病、中风和癌症史的个体以及随访头2年内死亡的个体后，结果不变。
在本研究中，在家中和运动时进行的身体活动与较低的死亡风险相关，而与职业和交通相关的活动则不然。宣传在家中和运动时进行身体活动的潜在益处，对于老年人群可能是一条重要的公共卫生信息。
