McLorie Gordon A
School of Medicine, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA.
Adv Urol. 2008;2008:459630. doi: 10.1155/2008/459630. Epub 2008 Oct 8.
We present a retrospective review of the scientific and clinical advances, extending over four decades, which have linked vesicoureteral reflux, with renal injury, and urinary tract infection. We have traced the original studies, coupled with advances in technology which led to the awareness, and ability to detect and diagnose the problems early in childhood. These advances progressed through clinical studies which defined the epidemiology of both reflux and urinary tract infection. Along with these diagnostic advances, there were numerous surgical developments, which allowed progressive improvements in the outcomes and effectiveness of a variety of treatment modalities. All of this literature leads us to the current era, when several clinical trials are currently underway in an effort to more fully define the most efficacious and safe methods to treat vesicoureteral reflux and associated urinary tract infection.
我们对四十多年来将膀胱输尿管反流与肾损伤及尿路感染联系起来的科学与临床进展进行了回顾。我们追溯了最初的研究，以及技术进步，这些进步使人们认识到并能够在儿童早期检测和诊断这些问题。这些进展是通过临床研究实现的，这些研究明确了反流和尿路感染的流行病学情况。伴随着这些诊断方面的进展，还有众多手术方面的发展，使得各种治疗方式的疗效和有效性得到了逐步改善。所有这些文献引领我们进入了当前这个时代，此时有多项临床试验正在进行，旨在更全面地确定治疗膀胱输尿管反流及相关尿路感染的最有效和安全的方法。
