Aslam Ejaz, Muhammad Tariq, Sharif Salman
Department of Neurosurgery, Liaquat National Hospital, Karachi, Pakistan.
J Pak Med Assoc. 2008 Sep;58(9):498-501.
To see the safety and efficacy of Percutaneous vertebroplasty in osteoporotic vertebral compression fractures.
This study was conducted at the Department of Neurosurgery, Liaquat National Hospital (LNH) Karachi, Pakistan. Patients with osteoporotic compression vertebral fractures, not responding to conservative treatment and having localized overlying tenderness and MRI evidence of high signal in the involved vertebral body, were included in the study. Visual Analogue Scale was used to measure the intensity of pain. Percutaneous vertebroplasty (PVP) was performed by injecting polymethylacrylate in the diseased vertebral body. The patients were followed up for initially 4 and 24 hours. Later they had a check up at 2 weeks, one three, six and twelve months.
Percutaneous vertebroplasty on twentyfour patients were included who underwent (LNH) from 2002 to 2006 Age range was from 65 to 85 years (mean age 75 +/- 3.3 years). Among 24 patients, 21 were females and 3 patients were male. Six patients had two levels osteoporotic compression vertebral fractures the rest, had compression at one level. Patients with radicular pain or signs of myelopathy, osteomyelitis of targeted vertebral body or overlying skin infection, severe compression of vertebral body or with retropulsed fragment into canal as evident by CT scan were excluded from the study. While patients who failed to respond to 6-12 weeks of conservative treatment, with localized overlying tenderness and MRI evident high signal in vertebral body involved, were included in the study. Visual analogue scale (VAS) was applied for the assessment of pain intensity. Followup was performed immediately, within 4 hours, after 24 hours, 2 weeks, 1 month, 3 months, 6 months and finally at one year.
Percutaneous vertebroplasty is a safe and useful procedure for the treatment of backache associated with osteoporotic vertebral compression fracture.
观察经皮椎体成形术治疗骨质疏松性椎体压缩骨折的安全性和有效性。
本研究在巴基斯坦卡拉奇利亚卡特国家医院神经外科进行。纳入患有骨质疏松性压缩性椎体骨折、对保守治疗无反应且局部有压痛且MRI显示受累椎体有高信号的患者。采用视觉模拟评分法测量疼痛强度。经皮椎体成形术（PVP）通过向患病椎体注射聚甲基丙烯酸甲酯来进行。患者最初随访4小时和24小时。随后在2周、1个月、3个月、6个月和12个月进行检查。
纳入了2002年至2006年在利亚卡特国家医院接受经皮椎体成形术的24例患者。年龄范围为65至85岁（平均年龄75±3.3岁）。24例患者中，21例为女性，3例为男性。6例患者有两个节段的骨质疏松性压缩性椎体骨折，其余患者为一个节段压缩。有神经根性疼痛或脊髓病体征、目标椎体骨髓炎或覆盖皮肤感染、椎体严重压缩或CT扫描显示有碎骨片突入椎管的患者被排除在研究之外。而对6至12周保守治疗无反应、局部有压痛且MRI显示受累椎体有明显高信号的患者被纳入研究。采用视觉模拟量表（VAS）评估疼痛强度。分别在术后即刻、4小时内、24小时后、2周、1个月、3个月、6个月，最后在1年时进行随访。
经皮椎体成形术是治疗与骨质疏松性椎体压缩骨折相关背痛的一种安全有效的方法。
