[视神经脊髓炎的严重发作：血浆置换后显著改善]

[Severe bouts of neuromyelitis optica: dramatic improvement after plasma exchanges].

作者信息

Bonnan M, Brasme H, Diaby M M, Vlaicu M, Le Guern V, Zuber M

机构信息

Service de neurologie et neurovasculaire, groupe hospitalier Paris Saint-Joseph, 75014 Paris, France.

出版信息

Rev Neurol (Paris). 2009 May;165(5):479-81. doi: 10.1016/j.neurol.2008.08.005. Epub 2008 Oct 9.

DOI:10.1016/j.neurol.2008.08.005

PMID:18848342

Abstract

Severe relapses are common in neuromyelitis optica (NMO). Plasma exchanges (PE) were successfully used to treat acute demyelinating relapses resistant to corticosteroids. However, little is known about PE efficiency in NMO relapses, particularly in relation with the presence or not of specific antibodies. We here report two patients with NMO (one seropositive and one seronegative) with dramatic improvement after PE on both the optical and spinal involvement.

摘要

视神经脊髓炎（NMO）中严重复发很常见。血浆置换（PE）已成功用于治疗对皮质类固醇耐药的急性脱髓鞘性复发。然而，关于PE在NMO复发中的疗效知之甚少，尤其是与特定抗体的有无之间的关系。我们在此报告两名NMO患者（一名血清阳性，一名血清阴性），在进行PE治疗后，其眼部和脊髓病变均有显著改善。