Le Guern Véronique, Pannier Emmanuelle, Goffinet François
Service de Médecine Interne, Hôpital Cochin, Université Paris Descartes, Paris, France.
Presse Med. 2008 Nov;37(11):1627-35. doi: 10.1016/j.lpm.2008.09.001. Epub 2008 Oct 9.
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that predominantly affects women of childbearing age. Prognosis of SLE pregnancy has dramatically improved with the advent in therapeutic management of SLE and in the obstetric care. Consequently, pregnancy is possible in SLE patients when the disease is inactive for at least 6 months. Because of the risk of lupus flare and obstetrical complications (fetal loss, preterm birth, intrauterine growth retardation, preeclampsia), a multidisciplinary approach, associating medical and obstetrical teams, is required. Corticosteroids, hydroxychloroquine and azathioprine are safe in pregnancy and should be kept when necessary.
系统性红斑狼疮（SLE）是一种复杂的自身免疫性疾病，主要影响育龄女性。随着SLE治疗管理和产科护理的进展，SLE患者妊娠的预后已显著改善。因此，当疾病至少6个月无活动时，SLE患者可以妊娠。由于存在狼疮病情复发及产科并发症（胎儿丢失、早产、胎儿生长受限、先兆子痫）的风险，需要医疗团队和产科团队联合采取多学科方法。皮质类固醇、羟氯喹和硫唑嘌呤在孕期是安全的，必要时应继续使用。
