Akpinar Zehra, Tokgöz Serhat, Gökbel Hakki, Okudan Nilsel, Uğuz Faruk, Yilmaz Gülsüm
Department of Neurology, Meram Faculty of Medicine, Selçuk University, Konya, Turkey.
Psychiatry Res. 2008 Nov 30;161(2):253-7. doi: 10.1016/j.psychres.2007.11.022. Epub 2008 Oct 10.
The association of nocturnal serum melatonin levels was investigated in acute multiple sclerosis (MS) patients with major depression (MD). The sample comprised 13 patients with MD and 12 with no psychiatric disorders admitted to our clinic due to acute MS attacks. Psychiatric evaluation was performed with the Structured Clinical Interview for DSM-IV (SCD-I). The level of depressive symptoms was assessed with the Beck Depression Scale (BDS). Blood samples were taken from the patients to determine melatonin level at 03.30 h and 10.00 h before steroid treatment started. Melatonin levels were determined using the ELISA test. Nocturnal serum melatonin levels (21.2+/-17.1 pg/ml) of the patients with MD were significantly lower than those (51.5+/-18.3 pg/ml) of the patients without MD. A significant negative correlation was found between BDS scores and nocturnal serum melatonin levels. These findings suggest that a melatonin deficiency may be among the factors involved in the occurrence of depression in MS patients.
研究了伴有重度抑郁（MD）的急性多发性硬化症（MS）患者夜间血清褪黑素水平的相关性。样本包括13例患有MD的患者和12例因急性MS发作而入住我们诊所且无精神疾病的患者。使用《精神疾病诊断与统计手册》第四版结构化临床访谈（SCD - I）进行精神评估。用贝克抑郁量表（BDS）评估抑郁症状水平。在开始使用类固醇治疗前，于凌晨03:30和上午10:00采集患者血样以测定褪黑素水平。使用酶联免疫吸附测定（ELISA）试验测定褪黑素水平。患有MD的患者夜间血清褪黑素水平（21.2±17.1 pg/ml）显著低于无MD的患者（51.5±18.3 pg/ml）。BDS评分与夜间血清褪黑素水平之间存在显著负相关。这些发现表明，褪黑素缺乏可能是MS患者发生抑郁的相关因素之一。
