Schmitz F, Hartmann H, Stümpel F, Creutzfeldt W
Department of Medicine, University of Göttingen, FRG.
Diabetologia. 1991 Mar;34(3):144-9. doi: 10.1007/BF00418267.
The acute metabolic actions of insulin-like growth factor I were studied in anaesthetized adult rats and its potency was compared to that of insulin. Following an i.v. bolus injection of insulin-like growth factor I a dose-dependent decrease of blood glucose and serum non-esterified fatty acid concentrations was noted with a potency of about 2% that of insulin. Stimulation of total body glucose disposal during euglycaemic clamping required approximately 50 times higher insulin-like growth factor I serum concentrations to achieve an identical half-maximal response. A similar difference in potency was observed for the stimulatory action on 2-deoxyglucose uptake and on glycogen formation in skeletal muscle. Lipogenesis in epididymal fat pads was increased dose-dependently by both hormones requiring approximately 30 times higher half-maximally effective serum concentrations of insulin-like growth factor I. These data demonstrate that insulin-like growth factor I exerted acute insulin-like metabolic actions in vivo with low potency. These effects were probably mediated via insulin receptors. A preferential stimulation of glucose metabolism in skeletal muscle was not observed.
在麻醉的成年大鼠中研究了胰岛素样生长因子I的急性代谢作用，并将其效力与胰岛素进行了比较。静脉推注胰岛素样生长因子I后，观察到血糖和血清非酯化脂肪酸浓度呈剂量依赖性下降，其效力约为胰岛素的2%。在正常血糖钳夹期间刺激全身葡萄糖处置，需要大约高50倍的胰岛素样生长因子I血清浓度才能达到相同的半最大反应。在对骨骼肌中2-脱氧葡萄糖摄取和糖原形成的刺激作用方面也观察到了类似的效力差异。两种激素均使附睾脂肪垫中的脂肪生成呈剂量依赖性增加，胰岛素样生长因子I的半最大有效血清浓度大约高30倍。这些数据表明，胰岛素样生长因子I在体内发挥急性胰岛素样代谢作用，效力较低。这些作用可能是通过胰岛素受体介导的。未观察到对骨骼肌葡萄糖代谢的优先刺激作用。
