Rivers Leanne E, Young Kaylene M, Rizzi Matteo, Jamen Françoise, Psachoulia Konstantina, Wade Anna, Kessaris Nicoletta, Richardson William D
Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK.
Nat Neurosci. 2008 Dec;11(12):1392-401. doi: 10.1038/nn.2220. Epub 2008 Oct 8.
Platelet-derived growth factor alpha receptor (PDGFRA)/NG2-expressing glia are distributed throughout the adult CNS. They are descended from oligodendrocyte precursors (OLPs) in the perinatal CNS, but it is not clear whether they continue to generate myelinating oligodendrocytes or other differentiated cells during normal adult life. We followed the fates of adult OLPs in Pdgfra-creER(T2)/Rosa26-YFP double-transgenic mice and found that they generated many myelinating oligodendrocytes during adulthood; >20% of all oligodendrocytes in the adult mouse corpus callosum were generated after 7 weeks of age, raising questions about the function of the late-myelinating axons. OLPs also produced some myelinating cells in the cortex, but the majority of adult-born cortical cells did not appear to myelinate. We found no evidence for astrocyte production in gray or white matter. However, small numbers of projection neurons were generated in the forebrain, especially in the piriform cortex, which is the main target of the olfactory bulb.
表达血小板源性生长因子α受体（PDGFRA）/NG2的神经胶质细胞分布于整个成年中枢神经系统（CNS）。它们源自围产期CNS中的少突胶质细胞前体细胞（OLP），但尚不清楚它们在正常成年期是否继续产生髓鞘形成少突胶质细胞或其他分化细胞。我们追踪了Pdgfra-creER(T2)/Rosa26-YFP双转基因小鼠成年OLP的命运，发现它们在成年期产生了许多髓鞘形成少突胶质细胞；成年小鼠胼胝体中超过20%的少突胶质细胞是在7周龄后产生的，这引发了关于晚期髓鞘形成轴突功能的问题。OLP在皮质中也产生了一些髓鞘形成细胞，但大多数成年新生皮质细胞似乎并未形成髓鞘。我们没有发现灰质或白质中产生星形胶质细胞的证据。然而，在前脑，特别是在嗅球的主要靶标梨状皮质中产生了少量投射神经元。
