• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Protective effect of epigallocatechin-3-gallate on ischemia/reperfusion-induced injuries in the heart: STAT1 silencing flavonoid.表没食子儿茶素没食子酸酯对缺血/再灌注诱导的心脏损伤的保护作用：沉默 STAT1 的黄酮类化合物。
Genes Nutr. 2007 Dec;2(3):307-10. doi: 10.1007/s12263-007-0060-3. Epub 2007 Oct 11.
2
Use of STAT1 inhibitors in the treatment of brain I/R injury and neurodegenerative diseases.STAT1抑制剂在治疗脑缺血再灌注损伤和神经退行性疾病中的应用。
Cent Nerv Syst Agents Med Chem. 2011 Mar 1;11(1):2-7. doi: 10.2174/187152411794961077.
3
Epigallocatechin, a green tea polyphenol, attenuates myocardial ischemia reperfusion injury in rats.表没食子儿茶素，一种绿茶多酚，可减轻大鼠心肌缺血再灌注损伤。
Mol Med. 2004 Jan-Jun;10(1-6):55-62. doi: 10.2119/2004-00032.aneja.
4
Direct interaction of natural and synthetic catechins with signal transducer activator of transcription 1 affects both its phosphorylation and activity.天然和合成儿茶素与信号转导转录激活因子 1 的直接相互作用影响其磷酸化和活性。
FEBS J. 2014 Feb;281(3):724-38. doi: 10.1111/febs.12618. Epub 2013 Dec 10.
5
Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis.表没食子儿没食子酸酯抑制信号转导和转录激活因子-1（STAT-1）的激活，并保护心肌细胞免受缺血/再灌注诱导的凋亡。
FASEB J. 2004 Oct;18(13):1621-3. doi: 10.1096/fj.04-1716fje. Epub 2004 Aug 19.
6
Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved.纯化的绿茶和红茶多酚对H-ras转化细胞中激活蛋白1活性及细胞生长的抑制作用：构效关系及相关机制
Cancer Res. 1999 Sep 15;59(18):4610-7.
7
Epigallocatechin-3-gallate sensitizes IFN-γ-stimulated CD4+ T cells to apoptosis via alternative activation of STAT1.表没食子儿茶素-3-没食子酸酯通过信号转导和转录激活因子1（STAT1）的替代性激活使干扰素-γ（IFN-γ）刺激的CD4+ T细胞对凋亡敏感。
Int Immunopharmacol. 2014 Dec;23(2):434-41. doi: 10.1016/j.intimp.2014.09.014. Epub 2014 Sep 29.
8
Epigallocatechin-3-gallate, a green tea catechin, protects the heart against regional ischemia-reperfusion injuries through activation of RISK survival pathways in rats.表没食子儿茶素-3-没食子酸酯，一种绿茶儿茶素，通过激活大鼠的RISK存活通路来保护心脏免受局部缺血-再灌注损伤。
Arch Pharm Res. 2014 Aug;37(8):1079-85. doi: 10.1007/s12272-013-0309-x. Epub 2013 Dec 5.
9
Protective effect of epigallocatechin gallate, a major constituent of green tea, against renal ischemia-reperfusion injury in rats.绿茶主要成分表没食子儿茶素没食子酸酯对大鼠肾脏缺血再灌注损伤的保护作用。
Int Urol Nephrol. 2015 Aug;47(8):1429-35. doi: 10.1007/s11255-015-1030-0. Epub 2015 Jun 28.
10
STAT1 as a new molecular target of anti-inflammatory treatment.信号转导和转录激活因子1作为抗炎治疗的新分子靶点。
Curr Med Chem. 2005;12(16):1819-28. doi: 10.2174/0929867054546645.

引用本文的文献

1
Cellular Defensive Mechanisms of Tea Polyphenols: Structure-Activity Relationship.茶多酚的细胞防御机制：构效关系。
Int J Mol Sci. 2021 Aug 24;22(17):9109. doi: 10.3390/ijms22179109.
2
E3-ubiquitin ligase TRIM6 aggravates myocardial ischemia/reperfusion injury via promoting STAT1-dependent cardiomyocyte apoptosis.E3泛素连接酶TRIM6通过促进信号转导和转录激活因子1（STAT1）依赖的心肌细胞凋亡加重心肌缺血/再灌注损伤。
Aging (Albany NY). 2019 Jun 6;11(11):3536-3550. doi: 10.18632/aging.101995.
3
Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity.表没食子儿茶素没食子酸酯，一种典型的化学预防药物，可预防顺铂类耳毒性。
Cell Death Dis. 2017 Jul 13;8(7):e2921. doi: 10.1038/cddis.2017.314.
4
Role of STAT1 and Oxidative Stress in Gentamicin-Induced Hair Cell Death in Organ of Corti.信号转导和转录激活因子1（STAT1）及氧化应激在庆大霉素诱导的柯蒂氏器毛细胞死亡中的作用
Otol Neurotol. 2016 Oct;37(9):1449-56. doi: 10.1097/MAO.0000000000001192.
5
Insights into restrictive cardiomyopathy from clinical and animal studies.从临床和动物研究看限制型心肌病。
J Geriatr Cardiol. 2011 Sep;8(3):168-83. doi: 10.3724/SP.J.1263.2011.00168.
6
STAT1 deficiency in the heart protects against myocardial infarction by enhancing autophagy.心脏中 STAT1 的缺失通过增强自噬来保护心肌梗死。
J Cell Mol Med. 2012 Feb;16(2):386-93. doi: 10.1111/j.1582-4934.2011.01323.x.
7
Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells.绿茶多酚表没食子儿茶素没食子酸酯对人角膜上皮细胞的抗炎和抗氧化作用
Mol Vis. 2011 Feb 18;17:533-42.

本文引用的文献

1
In vivo and in vitro antitumor effect of a unique nutrient mixture on lung cancer cell line A-549.一种独特营养混合物对肺癌细胞系A-549的体内和体外抗肿瘤作用。
Exp Lung Res. 2006 Oct;32(9):441-53. doi: 10.1080/01902140601047658.
2
Green tea polyphenols in the prevention of colon cancer.绿茶多酚在结肠癌预防中的作用
Front Biosci. 2007 Jan 1;12:2309-15. doi: 10.2741/2233.
3
Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets.多酚类化合物在神经退行性疾病治疗中的新作用：对其细胞内靶点的综述
Eur J Pharmacol. 2006 Sep 1;545(1):51-64. doi: 10.1016/j.ejphar.2006.06.025. Epub 2006 Jun 17.
4
Tea flavanols inhibit angiotensin-converting enzyme activity and increase nitric oxide production in human endothelial cells.茶黄烷醇可抑制人内皮细胞中的血管紧张素转换酶活性并增加一氧化氮的生成。
J Pharm Pharmacol. 2006 Aug;58(8):1139-44. doi: 10.1211/jpp.58.8.0016.
5
Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea.肥胖与摄入咖啡因、麻黄碱、辣椒素和绿茶相关的产热作用。
Am J Physiol Regul Integr Comp Physiol. 2007 Jan;292(1):R77-85. doi: 10.1152/ajpregu.00832.2005. Epub 2006 Jul 13.
6
Antioxidant therapeutic targets in COPD.慢性阻塞性肺疾病中的抗氧化治疗靶点
Curr Drug Targets. 2006 Jun;7(6):707-20. doi: 10.2174/138945006777435254.
7
Beneficial effects of green tea--a review.绿茶的有益功效——综述
J Am Coll Nutr. 2006 Apr;25(2):79-99. doi: 10.1080/07315724.2006.10719518.
8
Signal transducers and activators of transcription (STATs): Novel targets of chemopreventive and chemotherapeutic drugs.信号转导及转录激活因子（STATs）：化学预防和化疗药物的新靶点。
Curr Cancer Drug Targets. 2006 Mar;6(2):107-21. doi: 10.2174/156800906776056491.
9
Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications.绿茶及其多酚类儿茶素：在癌症及非癌症领域的医学应用
Life Sci. 2006 Mar 27;78(18):2073-80. doi: 10.1016/j.lfs.2005.12.006. Epub 2006 Jan 30.
10
Tea, obesity, and diabetes.茶、肥胖与糖尿病。
Mol Nutr Food Res. 2006 Feb;50(2):188-210. doi: 10.1002/mnfr.200500109.

表没食子儿茶素没食子酸酯对缺血/再灌注诱导的心脏损伤的保护作用：沉默 STAT1 的黄酮类化合物。

Protective effect of epigallocatechin-3-gallate on ischemia/reperfusion-induced injuries in the heart: STAT1 silencing flavonoid.

机构信息

Section of Biochemistry, Department of Morphological and Biomedical Sciences, University of Verona, Verona, Italy.

出版信息

Genes Nutr. 2007 Dec;2(3):307-10. doi: 10.1007/s12263-007-0060-3. Epub 2007 Oct 11.

DOI:10.1007/s12263-007-0060-3
PMID:18850185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2474938/
Abstract

The beneficial effect of naturally occurring flavonoids in health is believed to be due to their strong antioxidant activity. However, recent laboratory evidence indicates the involvement of a more specific action. Here, we present evidence that, among a number of catechins present in green tea extract, only epigallocatechin-3-gallate (EGCG) exerts a strong inhibitory action on interferon-gamma-elicited activation of signal transducer and activator of transcription 1 (STAT1). Protective action of EGCG in ischemia/reperfusion injury in the heart and the molecular mechanism of action, which has nothing to do with its anti-oxidant capacity are described.

摘要

人们认为，天然存在的类黄酮对健康的有益影响是由于其强大的抗氧化活性。然而，最近的实验室证据表明，还涉及更具体的作用。在这里，我们提出了这样的证据，即在绿茶提取物中存在的多种儿茶素中，只有表没食子儿茶素-3-没食子酸酯（EGCG）对干扰素-γ诱导的信号转导和转录激活因子 1（STAT1）的激活具有强烈的抑制作用。描述了 EGCG 在心脏缺血/再灌注损伤中的保护作用及其作用机制，这与它的抗氧化能力无关。