Ebner F H, Mariotto S, Darra E, Suzuki H, Cavalieri E
Dipartimento di Scienze Morfologico-Biomediche, Università di Verona, Verona, Italy.
Cent Nerv Syst Agents Med Chem. 2011 Mar 1;11(1):2-7. doi: 10.2174/187152411794961077.
In the etiology of brain injury associated to ischemia/reperfusion (I/R) and neurodegenerative diseases, a critical involvement of excessive activation of signal transducer and activator of transcription 1 (STAT1) and successive induction of iNOS expression has widely been evidenced. Any compound capable to down-regulate STAT1 activation seems to represent a new, promising anti-inflammatory drug. Among plant compounds, only a few have shown to possess anti-STAT1 activity. Among them, epigallocatechin-3-gallate (EGCG), the main polyphenol present in green tea leaves, efficiently protects heart from I/R injury and this action is strictly correlated to its anti-STAT1 property. Hyperforin, the non-polyphenolic compound present in St. John's wort, attenuates β-cell death induced by interferon-γ (IFN-γ) by strongly down-regulating STAT1 activation. STAT1, therefore, seems to represent a new molecular target of the protective treatment also against brain injury associated to a number of brain pathologies. Either understanding the molecular mechanism of anti-STAT1 action of these compounds or identification of other anti-STAT1 compounds are urged.
在与缺血/再灌注（I/R）相关的脑损伤及神经退行性疾病的病因学中，信号转导和转录激活因子1（STAT1）过度激活以及随后诱导诱导型一氧化氮合酶（iNOS）表达的关键作用已得到广泛证实。任何能够下调STAT1激活的化合物似乎都代表一种新的、有前景的抗炎药物。在植物化合物中，只有少数几种显示出具有抗STAT1活性。其中，表没食子儿茶素-3-没食子酸酯（EGCG）是绿茶中主要的多酚类物质，能有效保护心脏免受I/R损伤，且这一作用与其抗STAT1特性密切相关。贯叶连翘中含有的非多酚类化合物金丝桃素，通过强烈下调STAT1激活来减轻干扰素-γ（IFN-γ）诱导的β细胞死亡。因此，STAT1似乎代表了针对多种脑部疾病相关脑损伤的保护性治疗的新分子靶点。迫切需要了解这些化合物抗STAT1作用的分子机制，或鉴定其他抗STAT1化合物。
