Al-Abdwani Raghad M, Khamis Faryal A, Balkhair Abdullah, Sacharia Mathew, Wali Yasser A
Department of Child Health, Sultan Qaboos University, Al-Khoudh, Oman.
Pediatr Hematol Oncol. 2008 Sep;25(7):699-703. doi: 10.1080/08880010802341724.
Human parvovirus B19 (HPV B19) infections are usually asymptomatic or benign and self-limiting. In immunocompromised patients and patients with chronic hemolytic anemia, it can lead to transient red cell aplasia. Few reports in the literature have implicated HPV B19 as the possible cause of acute hepatitis and severe aplastic anemia in immunocompetent patients. Here, the authors report a previously healthy 6-year-old girl with acute hepatitis and severe aplastic anemia associated with HPV B19 infection diagnosed by serology (ELISA). Other common causes of these manifestations were ruled out. The clinical manifestations subsequently improved significantly with the use of immunosuppressive therapy confirming an autoimmune mechanism.
人细小病毒B19（HPV B19）感染通常无症状或为良性且自限性。在免疫功能低下的患者和慢性溶血性贫血患者中，它可导致短暂的红细胞再生障碍。文献中很少有报道指出HPV B19可能是免疫功能正常患者急性肝炎和严重再生障碍性贫血的病因。在此，作者报告了一名先前健康的6岁女孩，她患有与HPV B19感染相关的急性肝炎和严重再生障碍性贫血，通过血清学（ELISA）诊断。排除了这些表现的其他常见病因。随后，使用免疫抑制疗法后临床表现显著改善，证实了自身免疫机制。
