Zhang L Y, Liu F, Chen X, Zhang X Y, Ren Y Y, Zhang R R, Yang W Y, Guo Y
State Key Laboratory of Experimental Hematology; National Clinical Research Center for Blood Diseases; Children's Blood Disease Diagnosis and Treatment Center, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Zhonghua Xue Ye Xue Za Zhi. 2021 Aug 14;42(8):654-659. doi: 10.3760/cma.j.issn.0253-2727.2021.08.007.
To retrospectively analyze hemogram and bone marrow characteristics of pediatric patients infected with parvovirus B19 (HPV-B19) after hematopoietic reconstitution following allo-hematopoietic stem cell transplantation. The clinical course of nine patients with HPV-B19 infection, including hemogram and bone marrow smear analysis during infection, were retrospectively analyzed. Despite the hematological heterogeneity, all patients exhibited reduced hemoglobin levels accompanied by reticulocytes. The proportion and absolute count of reticulocytes decreased by 90.4% (24.7% -98.7% ) and 90.7% (18.6% -99.0% ) , respectively, in one week. Additionally, five patients manifested a decline in neutrophil granulocyte count in peripheral blood whereas granulocytic hypoplasia was not observed in bone marrow. Furthermore, six patients exhibited megakaryocytic hypoplasia in bone marrow, including five patients with decreased platelet counts in peripheral blood. Importantly, only some patients exhibited erythroid hypoplasia although all patients exhibited a decline in hemoglobin in peripheral blood. Erythroid hypoplasia in bone marrow was present in five patients. There was heterogeneity in hemogram and bone marrow smear characteristics among pediatric patients infected with HPV-B19 following allo-hematopoietic stem cell transplantation. Anemia accompanied by decreased reticulocyte count should prompt screening for HPV-B19 in these patients.
回顾性分析异基因造血干细胞移植后造血重建的小儿患者感染细小病毒B19（HPV-B19）后的血常规及骨髓特征。回顾性分析9例HPV-B19感染患者的临床病程，包括感染期间的血常规及骨髓涂片分析。尽管血液学表现存在异质性，但所有患者均出现血红蛋白水平降低并伴有网织红细胞。一周内网织红细胞比例和绝对计数分别下降了90.4%（24.7%-98.7%）和90.7%（18.6%-99.0%）。此外，5例患者外周血中性粒细胞计数下降，而骨髓中未观察到粒细胞发育不全。此外，6例患者骨髓中巨核细胞发育不全，其中5例患者外周血血小板计数下降。重要的是，尽管所有患者外周血血红蛋白均下降，但只有部分患者出现红系发育不全。5例患者骨髓中存在红系发育不全。异基因造血干细胞移植后感染HPV-B19的小儿患者血常规及骨髓涂片特征存在异质性。伴有网织红细胞计数降低的贫血应促使对这些患者进行HPV-B19筛查。
