Siso-Nadal Fernando, Otani Niels F, Gilmour Robert F, Fox Jeffrey J
Gene Network Sciences, Ithaca, New York 14850, USA.
Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Sep;78(3 Pt 1):031925. doi: 10.1103/PhysRevE.78.031925. Epub 2008 Sep 29.
Heterogeneity of cardiac electrical properties can lead to heart rhythm disorders. Numerical studies have shown that stimuli chosen to maximize dynamic heterogeneity terminate wave propagation. However, experimental investigations suggest that similar sequences induce fragmentation of the wave fronts, rather than complete wave block. In this paper we show that an insulating boundary in an otherwise homogeneous medium can disrupt dynamically induced wave block by breaking a symmetry in the spatial pattern of action potential duration, leading to unidirectional block and reentrant activation.
心脏电特性的异质性可导致心律失常。数值研究表明，选择使动态异质性最大化的刺激可终止波传播。然而，实验研究表明，类似序列会导致波前碎片化，而非完全的波阻断。在本文中，我们表明，在原本均匀的介质中的绝缘边界可通过打破动作电位持续时间空间模式的对称性来破坏动态诱导的波阻断，从而导致单向阻断和折返激活。
