School of Physics, Georgia Institute of Technology, Atlanta, GA 30332.
Proc Natl Acad Sci U S A. 2022 Jun 14;119(24):e2117568119. doi: 10.1073/pnas.2117568119. Epub 2022 Jun 9.
We identify and demonstrate a universal mechanism for terminating spiral waves in excitable media using an established topological framework. This mechanism dictates whether high- or low-energy defibrillation shocks succeed or fail. Furthermore, this mechanism allows for the design of a single minimal stimulus capable of defibrillating, at any time, turbulent states driven by multiple spiral waves. We demonstrate this method in a variety of computational models of cardiac tissue ranging from simple to detailed human models. The theory described here shows how this mechanism underlies all successful defibrillation and can be used to further develop existing and future low-energy defibrillation strategies.
我们利用已建立的拓扑框架，确定并展示了一种在兴奋介质中终止螺旋波的通用机制。该机制决定了高能或低能除颤冲击是成功还是失败。此外，该机制允许设计一个单一的最小刺激，能够在任何时候对由多个螺旋波驱动的湍流状态进行除颤。我们在从简单到详细的人类模型的各种心脏组织计算模型中展示了这种方法。这里描述的理论表明了这种机制如何构成所有成功除颤的基础，并可用于进一步开发现有的和未来的低能量除颤策略。
