Pelech A N, Allard S M, Hurd R T, Giddins N G, Collins G F
Variety Children's Heart Centre, University of Manitoba, Winnipeg, Canada.
Invest Radiol. 1991 Jul;26(7):665-70. doi: 10.1097/00004424-199107000-00008.
Iohexol (Omnipaque) and meglumine and sodium diatrizoate (Renografin-76) were compared in a double-blind, randomized study for their efficacy, safety, and hemodynamic effects as angiographic contrast agents in children. Forty-four children were randomly allocated to receive either iohexol or diatrizoate as a component of their routine or emergency cardiovascular evaluation. Following age stratification, baseline physiologic parameters were not significantly different between patients receiving either iohexol or diatrizoate. After systemic ventricular injection, iohexol produced significantly less hemodynamic alteration in systemic systolic blood pressure, systemic ventricular end-diastolic pressure, and dP/dt. Less alteration in heart rate and significantly less effect on the QT interval were seen with iohexol. Image quality was comparable, although significantly more patient mobility was associated with diatrizoate-meglumine. This study shows that iohexol, a nonionic contrast medium, causes less hemodynamic disturbance than diatrizoate-meglumine in children. Therefore, its use to be preferred in these potentially high-risk patients.
在一项双盲随机研究中，对碘海醇（欧乃派克）与泛影葡胺（Renografin - 76）作为儿童血管造影造影剂的疗效、安全性和血流动力学效应进行了比较。44名儿童被随机分配接受碘海醇或泛影葡胺作为其常规或紧急心血管评估的一部分。进行年龄分层后，接受碘海醇或泛影葡胺的患者之间基线生理参数无显著差异。经静脉注射后，碘海醇引起的全身收缩压、心室舒张末期压力和dP/dt的血流动力学改变明显较小。碘海醇对心率的影响较小，对QT间期的影响也明显较小。尽管使用泛影葡胺时患者移动明显更多，但图像质量相当。这项研究表明，非离子型造影剂碘海醇在儿童中引起的血流动力学干扰比泛影葡胺小。因此，在这些潜在高危患者中更倾向于使用碘海醇。
