急性外耳道炎微生物的鉴定及药敏试验
Identification and antimicrobial susceptibility of acute external otitis microorganisms.
作者信息
Nogueira Janaina Cândida Rodrigues, Melo Diniz Margareth de Fátima F, Lima Edeltrudes Oliveira, Lima Zilka Nandes
出版信息
Braz J Otorhinolaryngol. 2008 Jul-Aug;74(4):526-30. doi: 10.1016/s1808-8694(15)30598-x.
UNLABELLED
Acute external otitis is a polymicrobial infectious disease.
AIM
The purpose of this study was to isolate, identify and determine the Antimicrobial susceptibility of organisms causing otitis externa (OE).
METHODS
Twenty-seven swabs were taken from the ears of 27 patients with OE for culture and 22 microorganisms were isolate to evaluate sensitivity. In vitro susceptibility tests were performed by agar diffusion disk and results were interpreted according to Clinical Laboratory Standards.
RESULTS
10 Ear cultures were positive for S. aureus , 8 for P. aeruginosa, 5 for P. aeruginosa and S. aureus and 4 for fungal organisms (Candida albicans e C. Krusei). Gentamicin and quinolones were active against all bacteria tested and significant resistance to amoxicillin/clavulanate was observed. The tested species of Candida had been sensitive to amphothericin B, nystatin, fluconazole and clotrimazole and resistant to miconazole.
CONCLUSION
Acute external otitis is a polymicrobial infection and proper knowledge regarding microorganism etiology and susceptibility will contribute to rational antibiotic usage and treatment success.
未标注
急性外耳道炎是一种多微生物感染性疾病。
目的
本研究的目的是分离、鉴定并确定引起外耳道炎（OE）的微生物的抗菌药敏性。
方法
从27例OE患者的耳部采集27份拭子进行培养，分离出22种微生物以评估敏感性。采用琼脂扩散纸片法进行体外药敏试验，并根据临床实验室标准解读结果。
结果
10份耳部培养物金黄色葡萄球菌呈阳性，8份铜绿假单胞菌呈阳性，5份铜绿假单胞菌和金黄色葡萄球菌呈阳性，4份真菌（白色念珠菌和克柔念珠菌）呈阳性。庆大霉素和喹诺酮类药物对所有测试细菌均有活性，且观察到对阿莫西林/克拉维酸有显著耐药性。测试的念珠菌属对两性霉素B、制霉菌素、氟康唑和克霉唑敏感，对咪康唑耐药。
结论
急性外耳道炎是一种多微生物感染，关于微生物病因和药敏性的正确知识将有助于合理使用抗生素并取得治疗成功。
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