Di Santolo Manuela, Banfi Giuseppe, Stel Giuliana, Cauci Sabina
Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, 33100, Udine, Italy.
Eur J Appl Physiol. 2009 Jan;105(1):111-8. doi: 10.1007/s00421-008-0880-x. Epub 2008 Oct 14.
We assessed the influence of recreational physical activity in young healthy women on homocysteine, a potential risk factor for cardiovascular disease (CVD). Participants were 124 23-year-old normal-weight Italian recreational athletes (performing 8.7 +/- 2.46 h week(-1) exercise) and 116 controls. Median blood homocysteine, folate and lipid markers did not differ between athletes and controls. Elevated homocysteine levels at CVD risk > or =12.0 and > or =15.0 micromol l(-1) were not different between groups. Continuous homocysteine was inversely related to folate (P < 0.001), positively associated with age (P = 0.009) and creatinine (P = 0.033), but not associated with hours of exercise, body mass index, and lipid markers. Women with folate depletion (<3.0 microg l(-1)) were 4.5-fold more likely to have homocysteine > or =15.0 micromol l(-1). Recreational physical exercise does not adversely impact homocysteine levels among young women. Only low folate significantly increases the risk for hyperhomocysteinemia in young women.
我们评估了年轻健康女性的休闲体育活动对同型半胱氨酸（心血管疾病的一个潜在风险因素）的影响。参与者包括124名23岁体重正常的意大利休闲运动员（每周进行8.7±2.46小时锻炼）和116名对照者。运动员和对照者的血液同型半胱氨酸、叶酸和脂质标志物的中位数无差异。心血管疾病风险同型半胱氨酸水平升高≥12.0和≥15.0微摩尔/升时，两组之间无差异。连续同型半胱氨酸与叶酸呈负相关（P<0.001），与年龄（P = 0.009）和肌酐（P = 0.033）呈正相关，但与锻炼时间、体重指数和脂质标志物无关。叶酸缺乏（<3.0微克/升）的女性同型半胱氨酸≥15.0微摩尔/升的可能性高4.5倍。休闲体育锻炼不会对年轻女性的同型半胱氨酸水平产生不利影响。只有低叶酸会显著增加年轻女性高同型半胱氨酸血症的风险。
