Idova Galina, Davydova Svetlana, Alperina Elizaveta, Cheido Margarita, Devoino Lidia
Laboratory of Mechanisms of Neurochemical Modulation, State Research Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Int J Neurosci. 2008 Nov;118(11):1594-608. doi: 10.1080/00207450701768887.
The present study demonstrates the involvement of serotonin (5-HT) receptors of the 5-HT 1A type in immunoinhibitory effect of 5-HTergic system of the brain. A selective agonist of 5-HT 1A receptors 8-OH-DPAT (1 mg/kg) induces the immunosuppression, whereas 5-HT 1A blockade with WAY-100635 (1 mg/kg) resulted in immunostimulation. It is also shown that immunomodulating effects of the drugs were dependent on psychoemotional status of animals acquired aggressive or submissive behavior under social conflict conditions. Activation of 5-HT 1A receptors produced a decrease of the immunity in aggressive mice, whereas 5-HT 1A receptor blockade caused immunostimulation in submissive animals.
本研究证明了5-羟色胺（5-HT）能系统的5-HT 1A 型受体参与大脑免疫抑制作用。5-HT 1A 受体的选择性激动剂8-OH-DPAT（1毫克/千克）可诱导免疫抑制，而用 WAY-100635（1毫克/千克）阻断5-HT 1A 受体则导致免疫刺激。还表明，药物的免疫调节作用取决于动物在社会冲突条件下获得攻击或顺从行为时的心理情绪状态。5-HT 1A 受体的激活使攻击性小鼠的免疫力下降，而5-HT 1A 受体阻断则在顺从动物中引起免疫刺激。
