Popova N K, Naumenko V S, Pliusnina I Z
Zh Vyssh Nerv Deiat Im I P Pavlova. 2006 Jul-Aug;56(4):537-42.
The hypothesis was tested that one of the critical mechanisms underlying genetically determined aggressiveness involves brain serotonin 5-HT(1A)-receptors. The expression of 5-HT(1A)-receptor mRNA in brain structures and functional correlate for 5-HT(1A)-receptors identified as 8-OH-DPAT-induced hypothermia were studied in Norway rats bred over the course of 59 generations for the low and high affective (defensive) aggressiveness with respect to man and in highly aggressive (offensive) MAO A-knockout mice (Tg8 strain). Considerable differences between the aggressive and the nonaggressive animals were shown. Agonist of 5-HT(1A)-receptor 8-OH-DPAT (0.5 mg/kg for rats and 2.0 mg/kg for mice, i.p.) produced a distinct hypothermic reaction in nonaggressive rats and mice and did not affect significantly the body temperature in aggressive animals. In aggressive rats, a significant reduction of the expression of 5-HT(1A)-receptor mRNA was found in the midbrain. In Tg8 mice, 5-HT(1A)-receptor mRNA level was increased in the frontal cortex and amygdala and not changed in the hypothalamus and the midbrain. The results provide support for the idea that brain 5-HT(1A)-receptors contribute to the genetically determined individual differences in aggressiveness.
有一个假说得到了验证，即基因决定的攻击性背后的关键机制之一涉及大脑中的血清素5-HT(1A)受体。在经过59代培育的挪威大鼠中，研究了大脑结构中5-HT(1A)受体mRNA的表达以及被鉴定为8-OH-DPAT诱导的体温过低的5-HT(1A)受体的功能相关性，这些大鼠在对人类的低和高情感（防御性）攻击性方面有所不同，同时还研究了高攻击性（进攻性）的MAO A基因敲除小鼠（Tg8品系）。结果显示，攻击性动物和非攻击性动物之间存在显著差异。5-HT(1A)受体激动剂8-OH-DPAT（大鼠为0.5毫克/千克，小鼠为2.0毫克/千克，腹腔注射）在非攻击性大鼠和小鼠中产生了明显的体温过低反应，而对攻击性动物的体温没有显著影响。在攻击性大鼠的中脑中，发现5-HT(1A)受体mRNA的表达显著降低。在Tg8小鼠中，额叶皮质和杏仁核中的5-HT(1A)受体mRNA水平升高，而下丘脑和中脑中则没有变化。这些结果支持了大脑5-HT(1A)受体导致基因决定的攻击性个体差异这一观点。
