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[营养在预防年龄相关性黄斑变性中的作用]

[Nutrition in prevention of age-related macular degeneration].

作者信息

Szostak Wiktor B, Szostak-Wegierek Dorota

机构信息

Instytut Zywności i Zywienia, 02-903 Warszawa, ul. Powsińska 61/63,

出版信息

Przegl Lek. 2008;65(6):308-11.

Abstract

In the developed countries nowadays, there is an epidemy of age-related macular degeneration (AMD), what is caused by aging of the populations. Macular concentration of lutein and zeaxantin decreases with age, what exacerbates harmful effect of blue light on photoreceptors. Lutein and zeaxantin act as a filter of the high energy blue light. Besides, these carotenoids are strong antioxidants and neutralize light-generated free radicals. Plant foods are the exclusive dietary sources of the carotenoids. Macular lutein and zeaxantin concentrations are related to their consumption. Their average intake in the European countries is several times lower than 6 mg daily, what is the estimated recommended intake. The important role of high lutein and zeaxantin diet in AMD prevention is suggested. However, the results of the hitherto research are inconsistent. Use of lutein and zeaxantin supplements in patients with AMD resulted in sight improvement, what suggests the effeciveness of the supplements use both in prevention and treatment. However, there is a need of further research.

摘要

在当今发达国家,年龄相关性黄斑变性(AMD)呈流行态势,这是由人口老龄化引起的。随着年龄增长,黄斑中叶黄素和玉米黄质的含量会降低,这会加剧蓝光对光感受器的有害影响。叶黄素和玉米黄质可作为高能蓝光的滤光器。此外,这些类胡萝卜素是强大的抗氧化剂,可中和光产生的自由基。植物性食物是这些类胡萝卜素的唯一膳食来源。黄斑中叶黄素和玉米黄质的浓度与它们的摄入量有关。在欧洲国家,它们的平均摄入量比每日估计推荐摄入量6毫克低几倍。高叶黄素和玉米黄质饮食在预防AMD方面的重要作用得到了提示。然而,迄今为止的研究结果并不一致。在AMD患者中使用叶黄素和玉米黄质补充剂可改善视力,这表明补充剂在预防和治疗方面均有效。然而,仍需要进一步研究。

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