Horie A, Yano Y, Kotoo Y, Miwa A
Cancer. 1977 Jan;39(1):247-54. doi: 10.1002/1097-0142(197701)39:1<247::aid-cncr2820390138>3.0.co;2-f.
Two cases of infantile carcinoma of the pancreas were diagnosed as pancreatoblastoma based on the morphogenesis of the tumors. These encapsulated tumors adhered to the head of the pancreas and to the descending portion of the duodenum. Histologic examination revealed an organoid structure made up of cords or nodules of squamoid cells with elongated nuclei arranged in a parallel fasciculating pattern (squamoid corpuscles), surrounding tubular structures of columnar epithelial cells and intermediate light cell masses with little differentiation. Electron microscopy revealed zymogen-like granules and well developed granular endoplasmic reticulum in the cytoplasm. There were no detectable islet cells in tumor tissue. Both of these tumors could be derived from the ventral pancreas and be isolated by the lack of communication with the duct of Wirsung. As the duct of Santorini was patent, extirpation of these organoid tumors would not influence secretion of pancreatic juice. Considering the favorable prognosis after extirpation of these tumors, they should be differentiated from the usual adenocarcinoma of the pancreas occurring in adults.
根据肿瘤的形态发生，两例婴儿胰腺癌被诊断为胰母细胞瘤。这些包膜完整的肿瘤附着于胰头和十二指肠降部。组织学检查显示，肿瘤呈类器官结构，由鳞状细胞条索或结节组成，细胞核细长，呈平行束状排列（鳞状小体），围绕柱状上皮细胞的管状结构和分化程度低的中间淡染细胞团。电子显微镜检查显示，细胞质中有类酶原颗粒和发育良好的粗面内质网。肿瘤组织中未检测到胰岛细胞。这两种肿瘤可能均起源于腹侧胰腺，因与主胰管缺乏连通而孤立存在。由于副胰管通畅，切除这些类器官肿瘤不会影响胰液分泌。鉴于切除这些肿瘤后预后良好，应将其与成人常见的胰腺腺癌相鉴别。
