Sturmey Roger G, Brison Daniel R, Leese Henry J
Department of Biology, University of York, York, UK.
Reprod Biomed Online. 2008 Oct;17(4):486-96. doi: 10.1016/s1472-6483(10)60234-9.
This review assesses the ability of non-invasive 'amino acid profiling' to predict early embryo viability. The history of amino acid supplementation of embryo culture media and the role of amino acids in early embryo development are first considered and these are followed by a review of methods to quantify amino acid depletion and production by single embryos. Data on amino acid profiling of embryos from a number of species are then discussed. It is concluded that this technology has excellent potential to improve the selection of single embryos for transfer in clinical IVF.
本综述评估了非侵入性“氨基酸谱分析”预测早期胚胎活力的能力。首先考虑了胚胎培养基中氨基酸补充的历史以及氨基酸在早期胚胎发育中的作用，随后综述了量化单个胚胎氨基酸消耗和产生的方法。接着讨论了来自多个物种的胚胎氨基酸谱分析数据。得出的结论是，这项技术在改善临床体外受精中单个移植胚胎的选择方面具有巨大潜力。
