Alam S M, Bhatt A K
Department of Medicine, GSVM Medical College, Kanpur.
J Assoc Physicians India. 1991 Feb;39(2):170-1.
Observations of serum lipids and lipoproteins in 35 uraemic patients treated conservatively (20 cases) and by maintenance haemodialysis (15 cases) are presented. Serum triglycerides levels of both groups (243.7 +/- 119.1 and 160.8 +/- 55.0 mg/dl) were significantly higher (p less than 0.001) and high density lipoprotein cholesterol (HDLC) levels (19.0 +/- 6.1 and 12.17 +/- 5.1 mg/dl) were significantly lower (p less than 0.001) in comparison to those in 20 controls. Agarose gel electrophoresis revealed a second, slow migrating pre-beta band in significantly higher percentage of uraemics (55% and 93.3%) as compared to controls (25%). Until the effects of uraemia and chronic haemodialysis on lipoprotein metabolism are better understood, caution should be exercised in the interpretation of HDLC levels in these patients.
本文呈现了对35例保守治疗（20例）和维持性血液透析（15例）的尿毒症患者血清脂质和脂蛋白的观察结果。与20名对照组相比，两组患者的血清甘油三酯水平（分别为243.7±119.1和160.8±55.0mg/dl）显著更高（p<0.001），高密度脂蛋白胆固醇（HDLC）水平（分别为19.0±6.1和12.17±5.1mg/dl）显著更低（p<0.001）。琼脂糖凝胶电泳显示，与对照组（25%）相比，尿毒症患者中出现第二条缓慢迁移的前β带的比例显著更高（分别为55%和93.3%）。在更好地理解尿毒症和慢性血液透析对脂蛋白代谢的影响之前，对这些患者HDLC水平的解读应谨慎。
