Brown Sylvia B F, Morrison David S, Cooke Timothy G
University Department of Surgery, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, G31 2ER Scotland, UK.
Breast Cancer Res Treat. 2009 Aug;116(3):603-7. doi: 10.1007/s10549-008-0205-0. Epub 2008 Oct 15.
The incidence of breast cancer in post-menopausal women has been affected by the introduction of national breast screening programmes. The study describes the incidence of breast cancer in Scottish women aged 50-64 by year of birth before, during, and after the prevalent round of screening. Breast cancer registrations in Scotland for women aged 45-69 years from 1977 to 2003 were obtained. Birth cohort incidence rates were calculated and interpreted in the light of screening patterns at particular calendar time points. In the years before screening, there was a small rise in breast cancer incidence by birth cohort in women aged 50-54 which was not seen in other ages. During the prevalent screening round, incidence increased significantly with increasing birth cohort and thereafter continued rises in incidence by birth cohort occurred. The observed rise in breast cancer incidence among post-menopausal women is likely to be due to both screening effects and a true increase in incidence.
全国乳腺癌筛查项目的推行影响了绝经后女性乳腺癌的发病率。该研究描述了在首轮筛查之前、期间和之后，按出生年份划分的50 - 64岁苏格兰女性的乳腺癌发病率。获取了1977年至2003年苏格兰45 - 69岁女性的乳腺癌登记数据。根据特定日历时间点的筛查模式计算并解读出生队列发病率。在筛查前的几年里，50 - 54岁女性中按出生队列划分的乳腺癌发病率有小幅上升，其他年龄段未见此现象。在首轮筛查期间，发病率随出生队列的增加而显著上升，此后按出生队列划分的发病率持续上升。绝经后女性中观察到的乳腺癌发病率上升可能是筛查效应和发病率实际增加共同作用的结果。
