适配体——用于检测蛋白质的新型人工受体。
Aptabodies - new type of artificial receptors for detection proteins.
作者信息
Hianik T, Porfireva A, Grman I, Evtugyn G
机构信息
Department of Nuclear Physics and Biophysics, Comenius University, Mlynska dolina F1, 842 48 Bratislava, Slovakia.
出版信息
Protein Pept Lett. 2008;15(8):799-805. doi: 10.2174/092986608785203656.
PMID:18855752
Abstract
We report on a new type of artificial receptor formed by hybridization of two DNA aptamers for human thrombin (aptabody). This aptasensor based on multiwalled carbon nanotubes allowed us to detect thrombin with detection limit of 0.3 nM, which was 3 times better in comparison with conventional aptamer.
摘要
我们报道了一种由两种针对人凝血酶的DNA适配体杂交形成的新型人工受体（适配体抗体）。这种基于多壁碳纳米管的适配体传感器使我们能够检测凝血酶，检测限为0.3 nM，与传统适配体相比，检测效果提高了3倍。
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