Galimov A R, Kruglov A A, Bol'sheva N L, Iurkevich O Iu, Lipin'sh D Ia, Mufazalov I A, Kuprash D V, Nedospasov S A
Mol Biol (Mosk). 2008 Jul-Aug;42(4):629-38. doi: 10.1134/s0026893308040201.
Molecular organization, copy number and chromosomal localization of human TNF/LT locus fragment were determined in genomes of two transgenic mouse lines. Genome of the first one contains two copies, organized in head-to-tail manner and determined on eighth chromosome by karyotyping; single transgene copy of the second line is observed on the fifth chromosome. These mice could serve as valuable model for studying both human tumor necrosis factor and lymphotoxin physiological functions.
在两个转基因小鼠品系的基因组中确定了人类肿瘤坏死因子/淋巴毒素基因座片段的分子组织、拷贝数和染色体定位。第一个品系的基因组包含两个拷贝，以头对头的方式排列，通过核型分析确定位于第八号染色体上；第二个品系在第五号染色体上观察到单个转基因拷贝。这些小鼠可作为研究人类肿瘤坏死因子和淋巴毒素生理功能的宝贵模型。
