婴儿期巨细胞病毒感染时淋巴细胞亚群的改变。
Alteration of lymphocyte subpopulations with cytomegalovirus infection in infancy.
作者信息
Schauf V, Strelkauskas A J, Deveikis A
出版信息
Clin Exp Immunol. 1976 Dec;26(3):478-83.
Abstract
The distribution of immunoglobulin bearing (Ig+), T, and null lymphocyte subpopulations and the lymphocyte response to phytohaemagglutinin (PHA) and pokeweed mitogen (PWM) were determined in three infants with cytomegalovirus (CMV) infection. These infants had significantly decreased percentages of T cells (13%, 29% and 40%) compared to age-matched controls (61 +/- 2%). Compensatory increases in the percentages of Ig+ and null cells occurred. Decreased lymphocyte reactivity to PHA and PWM occurred in two patients. Purified T cells from these patients had normal reactivity indicating a disproportion of T cells in the peripheral blood. These abnormalities may result from CMV infection of lymphocytes and could be responsible for prolonged CMV viruria.
摘要
对三名巨细胞病毒（CMV）感染婴儿的免疫球蛋白阳性（Ig+）、T和裸淋巴细胞亚群分布以及淋巴细胞对植物血凝素（PHA）和商陆丝裂原（PWM）的反应进行了测定。与年龄匹配的对照组（61±2%）相比，这些婴儿的T细胞百分比显著降低（分别为13%、29%和40%）。Ig+和裸细胞百分比出现代偿性增加。两名患者对PHA和PWM的淋巴细胞反应性降低。这些患者的纯化T细胞具有正常反应性，表明外周血中T细胞比例失调。这些异常可能是淋巴细胞CMV感染所致，可能是CMV病毒尿持续时间延长的原因。
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本文引用的文献
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