MAGILL T P, SUGG J Y
J Exp Med. 1948 Jun 1;87(6):535-46. doi: 10.1084/jem.87.6.535.
Data are presented which enhance the idea that the influenza virus is an unstable agent. They indicate that the O-D type of variation is not a discontinuous mutation but rather is a reversible phenomenon. The O and the D forms of virus both appear to be inherent in the virus particle; the dominance of one or the other form seems to be subject to chance occurrences, but is influenced by the conditions under which the virus is propagated. The capacity of the O form of virus to agglutinate guinea pig but not chicken crythrocytes is a relative, not an absolute phenomenon; allantoic fluids which exhibit clear-cut O form hemagglutination may be made to exhibit D form merely by addition of suitable buffer to the test system. That point is of importance from the viewpoint of the mechanism of influenza virus hemagglutination.
所呈现的数据强化了流感病毒是一种不稳定因子的观点。这些数据表明，O-D型变异并非是一种间断性突变，而是一种可逆现象。病毒的O型和D型似乎都存在于病毒颗粒中；一种或另一种形式的主导地位似乎取决于偶然情况，但会受到病毒繁殖条件的影响。病毒O型凝集豚鼠红细胞而不凝集鸡红细胞的能力是相对的，而非绝对现象；仅仅通过向测试系统中添加合适的缓冲液，就可以使呈现明显O型血凝反应的尿囊液呈现D型血凝反应。从流感病毒血凝机制的角度来看，这一点很重要。
