豚鼠体内乙型流感病毒的传播。
Transmission of influenza B viruses in the guinea pig.
机构信息
Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA.
出版信息
J Virol. 2012 Apr;86(8):4279-87. doi: 10.1128/JVI.06645-11. Epub 2012 Feb 1.
Abstract
Epidemic influenza is typically caused by infection with viruses of the A and B types and can result in substantial morbidity and mortality during a given season. Here we demonstrate that influenza B viruses can replicate in the upper respiratory tract of the guinea pig and that viruses of the two main lineages can be transmitted with 100% efficiency between inoculated and naïve animals in both contact and noncontact models. Our results also indicate that, like in the case for influenza A virus, transmission of influenza B viruses is enhanced at colder temperatures, providing an explanation for the seasonality of influenza epidemics in temperate climates. We therefore present, for the first time, a small animal model with which to study the underlying mechanisms of influenza B virus transmission.
摘要
流行性感冒通常由 A 型和 B 型病毒感染引起，在特定季节可导致较高的发病率和死亡率。在这里，我们证明了 B 型流感病毒可在豚鼠的上呼吸道中复制，并且在接触和非接触模型中，两种主要谱系的病毒可以 100%有效地在接种和未感染的动物之间传播。我们的结果还表明，与甲型流感病毒一样，流感 B 型病毒的传播在较冷的温度下增强，这为温带气候中流感流行的季节性提供了一个解释。因此，我们首次提出了一种小动物模型，用于研究流感 B 型病毒传播的潜在机制。
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