Ikeuchi J, Yoshizaki T, Hirata M
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
J Toxicol Sci. 1991 May;16(2):49-59. doi: 10.2131/jts.16.49.
Plasma components of 6 to 12-month-old beagles were examined using a Technicon auto-analyzer. Age-related changes were noted for 8 of the 21 components: the levels of total protein (T. Pro) and iron (Fe) gradually increased while those of alkaline phosphatase (ALP), creatine phosphokinase (CPK) and inorganic phosphorus (Pi) persistently decreased in both sexes. Triglyceride (Trigly) in female dogs, glutamic-pyruvic transaminase (GPT) and urea nitrogen (Urea-N) in male dogs tended to increase. The following thirteen components showed no significant variation during the period of observation: glucose (Glu), lactic dehydrogenase (LDH), albumin (Alb), creatinine (Crea), glutamic-oxaloacetic transaminase (GOT), leucine aminopeptidase (LAP), total bilirubin (T. Bil), amylase (Amy), total cholesterol (T. Chol), sodium (Na), potassium (K), chloride (Cl) and calcium (Ca). Our results generally agree with the reported findings on beagles from various institutions.
使用Technicon自动分析仪对6至12月龄的比格犬的血浆成分进行了检测。在21种成分中的8种中发现了与年龄相关的变化：总蛋白（T. Pro）和铁（Fe）水平逐渐升高，而碱性磷酸酶（ALP）、肌酸磷酸激酶（CPK）和无机磷（Pi）水平在两性中持续下降。雌性犬的甘油三酯（Trigly）、雄性犬的谷丙转氨酶（GPT）和尿素氮（Urea-N）有升高趋势。在观察期间，以下13种成分没有显著变化：葡萄糖（Glu）、乳酸脱氢酶（LDH）、白蛋白（Alb）、肌酐（Crea）、谷草转氨酶（GOT）、亮氨酸氨肽酶（LAP）、总胆红素（T. Bil）、淀粉酶（Amy）、总胆固醇（T. Chol）、钠（Na）、钾（K）、氯（Cl）和钙（Ca）。我们的结果总体上与各机构对比格犬的报道结果一致。
