Tamaki S, Shinotsuka A, Takenaka H
Department of Radiology, Showa University School of Medicine.
Kaku Igaku. 1991 May;28(5):487-97.
We discovered that 99mTc-EHIDA commonly used for hepatobiliary scintigraphy could also be administered per-rectally, with adequate absorption and optimal visualization of the portal system. To evaluation its usefulness, we experimented on rabbits using the method. Portal scintigraphy with rectal administration of 99mTc-EHIDA, 123I-IMP and 99mTc-RBC were performed in normal rabbits and in extrahepatic portal shunt model rabbits. Images of the liver and thorax were obtained and shunt indices were calculated from the count values of liver and lung or heart. Then the shunt indices were compared with shunt rate derived from direct injection of 99mTc-MAA into inferior mesenteric vein. Correlation between shunt rate of 99mTc-MAA and shunt indices of 99mTc-RBC, 123I-IMP and 99mTc-EHIDA were 0.64, 0.75 and 0.78, respectively, with 99mTc-EHIDA having the most favourable results. We concluded that 99mTc-EHIDA per-rectal portal scintigraphy is a noninvasive, quantitative, inexpensive and simple method for evaluation of portal circulation system. Also, we think that this method would be applicable to human usage from our experience with normal volunteers.
我们发现，常用于肝胆闪烁显像的99m锝-二乙基乙酰苯胺（99mTc-EHIDA）也可经直肠给药，吸收良好且门静脉系统显像最佳。为评估其效用，我们用该方法在兔子身上进行了实验。对正常兔子和肝外门静脉分流模型兔子进行了经直肠给予99mTc-EHIDA、123碘-异碘普胺（123I-IMP）和99m锝标记红细胞（99mTc-RBC）后的门静脉闪烁显像。获取肝脏和胸部图像，并根据肝脏和肺部或心脏的计数计算分流指数。然后将分流指数与经肠系膜下静脉直接注射99mTc-大颗粒聚合人血清白蛋白（99mTc-MAA）得出的分流率进行比较。99mTc-MAA的分流率与99mTc-RBC、123I-IMP和99mTc-EHIDA的分流指数之间的相关性分别为0.64、0.75和0.78，其中99mTc-EHIDA的结果最为理想。我们得出结论，经直肠给予99mTc-EHIDA的门静脉闪烁显像是一种评估门静脉循环系统的无创、定量、廉价且简单的方法。此外，根据我们对正常志愿者的经验，我们认为该方法适用于人体。
