Shiomi S, Kuroki T, Ikeoka N, Fukuda K, Ueda T, Kobayashi K, Ochi H
Third Department of Internal Medicine, Osaka City University Medical School.
Kaku Igaku. 1993 Jul;30(7):735-41.
Liver scintigraphy using 99mTc-GSA, which binds specifically to the asialoglycoprotein receptors on the surface of the hepatocytes, was performed in 41 patients with chronic liver disease (11 chronic hepatitis cases and 30 liver cirrhosis) to investigate the correlations between the images and the various liver function tests. Two liver functional indexes, HH15 for plasma clearance of 99mTc-GSA and LHL15 for liver accumulation of 99mTc-GSA, showed significant differences between the chronic hepatitis group and the decompensated liver cirrhosis group. These indexes also showed significant correlations with the liver function tests such as serum albumin level and prothrombin time. HH15 and LHL15 correlated with the per-rectal portal shunt index obtained in 10 patients by 99mTcO4- per-rectal portal scintigraphy. These results suggest that HH15 and LHL15 have value as new liver functional indexes.
对41例慢性肝病患者（11例慢性肝炎和30例肝硬化）进行了使用99mTc-GSA的肝脏闪烁扫描，99mTc-GSA能特异性结合肝细胞表面的去唾液酸糖蛋白受体，以研究图像与各种肝功能检查之间的相关性。两个肝功能指标，即99mTc-GSA血浆清除率的HH15和99mTc-GSA肝脏摄取率的LHL15，在慢性肝炎组和失代偿期肝硬化组之间存在显著差异。这些指标还与血清白蛋白水平和凝血酶原时间等肝功能检查显示出显著相关性。HH15和LHL15与通过99mTcO4-经直肠门静脉闪烁扫描在10例患者中获得的经直肠门静脉分流指数相关。这些结果表明，HH15和LHL15作为新的肝功能指标具有价值。
