Bingham B, Wang R G, Hawke M, Kwok P
Department of Otolaryngology, University of Toronto, Ontario.
Laryngoscope. 1991 Sep;101(9):992-7. doi: 10.1288/00005537-199109000-00011.
This histological study of 20 fetal heads aged between 8 and 24 weeks of gestation demonstrates and describes the embryonic development of the lateral wall of the nose. The three turbinates (inferior, middle, and superior) arise as soft-tissue swellings (preturbinates) by 8 weeks' gestation. A cartilage capsule surrounds the nose at 8 weeks and by 9 weeks, medially directed flanges of cartilage have invaded all three preturbinates. The uncinate process arises from the medial surface of the lateral cartilaginous capsule and is first identifiable by 10 weeks. An "air space" progressively develops from 11 to 12 weeks lateral to the cartilaginous uncinate process and from this space, the embryonic channel to the maxillary sinus develops. The embryonic woven bone of the maxilla can be identified from 9 to 10 weeks and enlarges both absolutely and relatively to the nasal cavity, so that by 13 to 14 weeks, this expanding bone forms the lateral wall of the inferior meatus as the cartilaginous nasal capsule regresses.
这项对20个妊娠8至24周胎儿头部的组织学研究展示并描述了鼻侧壁的胚胎发育过程。妊娠8周时,三个鼻甲(下鼻甲、中鼻甲和上鼻甲)以软组织肿胀(鼻甲前体)的形式出现。妊娠8周时,一个软骨囊包绕着鼻子,到9周时,向内生长的软骨突侵入了所有三个鼻甲前体。钩突起源于外侧软骨囊的内表面,在10周时首次可辨认。在11至12周期间,在软骨性钩突外侧逐渐形成一个“气腔”,从这个气腔中,通向鼻窦的胚胎通道开始发育。上颌骨的胚胎编织骨在9至10周时可辨认,并相对于鼻腔在绝对和相对尺寸上都增大,因此到13至14周时,随着软骨性鼻囊退化,这块不断扩展的骨头形成了下鼻道的外侧壁。