Hiraki Y
First Department of Surgery, Kurume University School of Medicine, Japan.
Nihon Geka Gakkai Zasshi. 1991 Jun;92(6):645-51.
Experimental studies were performed to investigate the role, if any, of bile reflux in cancer development in the stomach. A 20% solution of human bile juice and 50 micrograms/ml of the known carcinogenic MNNG were given perorally and heterochronically to male Wistar rat, and the incidence of carcinoma in the gastric gland of the rat was studied. The animals were divided into 4 groups: Group I, to which only MNNG was given. Group II, to which human bile juice and then MNNG were administered. Group III, to which MNNG and then human bile juice were administered. And Group IV, to which only human bile juice was given. The incidence of cancer was 37.5% (3/8) in Group II, 25% (2/8) in Group III, and 0% in Group I (0/12) and IV (0/12). The gastric gland mucosa was histologically examined at various times and also by microautoradiography using 3H-TdR. The results suggested that a reverse flow of bile juice to the human remnant stomach may induce an increase in proliferative cells in the lacunar epithelia of the stomach mucosa and that a predisposed site would then be available for cancer development.
进行了实验研究，以调查胆汁反流在胃癌发生过程中（如果存在的话）所起的作用。将20%的人胆汁溶液和50微克/毫升已知致癌物质MNNG经口、异时给予雄性Wistar大鼠，并研究大鼠胃腺中癌的发生率。动物被分为4组：第一组，仅给予MNNG；第二组，先给予人胆汁，然后给予MNNG；第三组，先给予MNNG，然后给予人胆汁；第四组，仅给予人胆汁。第二组的癌症发生率为37.5%（3/8），第三组为25%（2/8），第一组（0/12）和第四组（0/12）为0%。在不同时间对胃腺黏膜进行组织学检查，并使用3H-TdR进行微放射自显影检查。结果表明，胆汁反流至人残胃可能会导致胃黏膜腺窝上皮中增殖细胞增多，进而为癌症发生提供一个易感部位。
