Bousquet E, Tirendi S, Santagati N A, Salvo M, Moncada Paterno Castello P
Istituto di Chimica Farmaceutica e Tossicologica, Facoltá di Farmacia, Università di Catania, Italy.
Pharmazie. 1991 Apr;46(4):257-8.
A method is reported for the determination of the anticonvulsant sodium valproate in serum by fluorimetric detection. HPLC is performed on a reversed-phase column with a mobile phase of acetonitrile/water (65:35, v/v) with cyclohexane carboxylic acid as an internal standard. Samples were derivatized with 4-bromomethyl-7-methoxycoumarin and the optimized conditions are reported.
报道了一种通过荧光检测法测定血清中抗惊厥药物丙戊酸钠的方法。采用反相柱进行高效液相色谱分析，流动相为乙腈/水（65:35，v/v），以环己烷羧酸作为内标。样品用4-溴甲基-7-甲氧基香豆素进行衍生化，并报道了优化条件。
